{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑1301‑3p plays context‐dependent roles across a spectrum of human diseases, particularly in cancer. In some malignancies it exhibits oncogenic behavior—for example, in prostate cancer, miR‑1301‑3p promotes cancer stem cell expansion by directly repressing Wnt pathway inhibitors such as GSK3β and SFRP1, and further drives cell cycle progression by downregulating tumor suppressors like PPP2R2C. In non‐small cell lung cancer, elevated levels of miR‑1301‑3p enhance proliferation, migration, invasion, and even radioresistance through inhibition of the homeodomain‐only protein HOPX. Conversely, in hepatocellular carcinoma, osteosarcoma, colorectal cancer, and triple‐negative breast cancer, miR‑1301‑3p acts as a tumor suppressor by targeting oncogenic factors including UBE4B, BCL9, and STAT3 and by potentiating p53 activity, thereby inhibiting cell growth and metastatic behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its intrinsic activity, miR‑1301‑3p is subject to regulation by a complex network of long non‑coding RNAs that function as competing endogenous RNAs. For instance, in osteosarcoma the lncRNA SNHG16 sequesters miR‑1301‑3p, leading to increased expression of BCL9, whereas in esophageal squamous cell carcinoma the lncRNA MIAT binds miR‑1301‑3p to de‐repress INCENP, thereby promoting proliferation and cell cycle progression. Similarly, in hepatocellular carcinoma, lncRNA LINC01433 suppresses miR‑1301‑3p to enable STAT3 upregulation, and in glioblastoma and diabetic retinopathy, other lncRNAs (including PVT1 and those yet to be fully characterized) modulate miR‑1301‑3p activity to affect targets such as TMBIM6 and KLF7. Moreover, in bone marrow mesenchymal stem cells, lncRNA DANCR sponges miR‑1301‑3p to relieve its inhibition of PROX1, thereby suppressing osteogenic differentiation. Preliminary studies in ovarian cancer further suggest that miR‑1301 may regulate cisplatin sensitivity, although its precise role in chemoresistance remains to be clarified."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its effects on cell proliferation and survival, miR‑1301‑3p modulates key signaling cascades and therapeutic responses. For example, in squamous cell carcinoma models, overexpression of miR‑1301‑3p results in significant downregulation of PI3K and reduced AKT phosphorylation, implicating inhibition of the PI3K/AKT pathway in its antitumor actions. In chronic myeloid leukemia, downregulation of RanGAP1 by miR‑1301 leads to nuclear entrapment of the oncogenic BCR‑ABL fusion protein and thereby enhances p73‐dependent apoptosis, which augments the efficacy of imatinib treatment. On the other hand, in non‑small cell lung cancer, heightened miR‑1301‑3p activity drives tumor progression and radioresistance via suppression of HOPX."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin Fang, Ning Yang, Jie Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1301-mediated inhibition of tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2011.1589"}], "href": "https://doi.org/10.3892/or.2011.1589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22159405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22159405"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei-Cheng Liang, Yan Wang, Li-Jia Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of miRNAs that specifically target tumor suppressive KLF6-FL rather than oncogenic KLF6-SV1 isoform."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/rna.29356"}], "href": "https://doi.org/10.4161/rna.29356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24921656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24921656"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tsung-Yao Lin, Ku-Chung Chen, Hsing-Jin Eugene Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0156260"}], "href": "https://doi.org/10.1371/journal.pone.0156260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27228340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27228340"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dongbin Bi, Hao Ning, Shuai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1301 promotes prostate cancer proliferation through directly targeting PPP2R2C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2016.03.043"}], "href": "https://doi.org/10.1016/j.biopha.2016.03.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27261573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27261573"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Benfan Wang, Hong Wu, Chengsen Chai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1301 suppresses tumor cell migration and invasion by targeting the p53/UBE4B pathway in multiple human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.04.038"}], "href": "https://doi.org/10.1016/j.canlet.2017.04.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28483517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28483517"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Q-L Bai, C-W Hu, X-R Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between downexpression of miR-1301 and poor prognosis in patients with glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29077167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29077167"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xian-Lu Song, Bin Huang, Bo-Wei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1301-3p promotes prostate cancer stem cell expansion by targeting SFRP1 and GSK3β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.01.086"}], "href": "https://doi.org/10.1016/j.biopha.2018.01.086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29358129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29358129"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qiuju Wu, Zekun Chen, Guihua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmy050"}], "href": "https://doi.org/10.1093/abbs/gmy050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29790898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29790898"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lei Wang, Kejun Hu, Yu Chao "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1301 inhibits migration and invasion of osteosarcoma cells by targeting BCL9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.08.078"}], "href": "https://doi.org/10.1016/j.gene.2018.08.078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30172867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30172867"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Haijin Huang, Yan-Zhi Bu, Xiao-Yu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01433 promotes hepatocellular carcinoma progression via modulating the miR-1301/STAT3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27366"}], "href": "https://doi.org/10.1002/jcp.27366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30317567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30317567"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xueli Wang, Kejun Hu, Yu Chao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG16 promotes proliferation, migration and invasion of osteosarcoma cells by targeting miR-1301/BCL9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.108798"}], "href": "https://doi.org/10.1016/j.biopha.2019.108798"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30909141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30909141"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lijun Yu, Min Meng, Yun Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1301/TRIAP1 Axis Participates in Epirubicin-Mediated Anti-Proliferation and Pro-Apoptosis in Osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yonsei Med J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3349/ymj.2019.60.9.832"}], "href": "https://doi.org/10.3349/ymj.2019.60.9.832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31433581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31433581"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chunyan Zhang, Linsen Xie, Yin Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p/INCENP axis and interacting with SOX2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29448"}], "href": "https://doi.org/10.1002/jcp.29448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31943174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31943174"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "J-L Yu, X Gao "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 1301 inhibits cisplatin resistance in human ovarian cancer cells by regulating EMT and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202002_20343"}], "href": "https://doi.org/10.26355/eurrev_202002_20343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32141535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32141535"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Z Jin, L-H Piao, G-C Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) promotes glioblastoma multiforme progression via regulating miR-1301-3p/TMBIM6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202011_23810"}], "href": "https://doi.org/10.26355/eurrev_202011_23810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33275233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33275233"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wei Weng, Shengdi Di, Shitong Xing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-021-04074-9"}], "href": "https://doi.org/10.1007/s11010-021-04074-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33629241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33629241"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Fangfang Yang, Hua Wang, Bianbian Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2020-0301"}], "href": "https://doi.org/10.1515/hsz-2020-0301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33984882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33984882"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaolin Lu, Liling Chen, Yang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01207 promotes cell proliferation and migration but suppresses apoptosis and autophagy in oral squamous cell carcinoma by the microRNA-1301-3p/lactate dehydrogenase isoform A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1972784"}], "href": "https://doi.org/10.1080/21655979.2021.1972784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34463208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34463208"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Chaofan Gong, Rohit Bhargava, Chandrajit Bajaj "}, {"type": "b", "children": [{"type": "t", "text": "Exploring the Study of miR-1301 Inhibiting the Proliferation and Migration of Squamous Cell Carcinoma YD-38 Cells through PI3K/AKT Pathway under Deep Learning Medical Images."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Intell Neurosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5865640"}], "href": "https://doi.org/10.1155/2022/5865640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35186067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35186067"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jianjin Guo, Yuan Chen, Jiajia Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA PVT1 regulates the proliferation and apoptosis of ARPE-19 cells "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " via the miR-1301-3p/KLF7 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2022.2058839"}], "href": "https://doi.org/10.1080/15384101.2022.2058839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35451342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35451342"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Mei Qu, Zhiliang Jin, Yanhua Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa-miR-1301-3p Promotes the Proliferation and Migration of Nonsmall Cell Lung Cancer Cells and Reduces Radiosensitivity via Targeting Homeodomain-Only Protein Homeobox."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2022.0214"}], "href": "https://doi.org/10.1089/gtmb.2022.0214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38156905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38156905"}]}]}]}