| HGNC Family | Non-coding RNAs |
| Name | microRNA 1302-1 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "characterizes a group of evolutionarily dynamic, testis‐expressed genes that share a common regulatory feature—a conserved CYPT promoter-like (CPL) element containing TATA and CCAAT boxes. Using refined homology searches, the investigators identified 39 loci in the human genome where this CPL element is present immediately upstream of genes from the VCX/Y, SPANX, and CSAG families. These genes exhibit expression profiles similar to the murine CYPT family, with predominant expression in spermatids and weaker expression in other germ cell types and somatic cells, suggesting common regulatory mechanisms and possibly a common ancestral origin. Although the abstract provides important insight into the architecture and evolution of these testis‐specific genes, it does not specifically address or assign any functional role to MIR1302-1. In the context of this study, no direct information about the function of MIR1302-1 is available.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Martin A Hansen, John E Nielsen, Dorota Retelska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.20651"}], "href": "https://doi.org/10.1002/mrd.20651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17342728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17342728"}]}]}]}
|
| Synonyms | MIRN1302-1, HSA-MIR-1302-1 |
| NCBI Gene ID | 100302227 |
| API | |
| Download Associations | |
| Predicted Functions |
![]() |
| Co-expressed Genes |
![]() |
| Expression in Tissues and Cell Lines |
![]() |
MIR1302-1 has 109 functional associations with biological entities spanning 1 categories (cell line, cell type or tissue) extracted from 1 datasets.
Click the + buttons to view associations for MIR1302-1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR1302-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |