MIR1304 Gene

HGNC Family Non-coding RNAs
Name microRNA 1304
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies across diverse malignancies have revealed that miR‑1304 plays critical roles in modulating tumor progression, primarily via interactions with circular RNAs that act as molecular sponges. For instance, in papillary thyroid cancer, circ_0025033 directly sponges miR‑1304 (along with miR‑1231) to promote cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in non‑small cell lung cancer (NSCLC), circ‑FOXM1 sequesters miR‑1304‑5p, thereby upregulating oncogenic targets such as PPDPF and MACC1 to enhance tumor cell growth and invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional evidence demonstrates that the miR‑1304 regulatory axis is pivotal in other cancers. In gastric cancer, circ‑PRMT5 binds miR‑1304 (in conjunction with miR‑145) to relieve repression of MYC, contributing to poorer patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In osteosarcoma, the oncogenic circ_0102049 sponges miR‑1304‑5p to upregulate MDM2 expression, ultimately fostering enhanced cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in glioma, circ_0074026 exerts its tumor‑promoting effect by sequestering miR‑1304, which normally targets the 3′‑untranslated region of ERBB4, thereby facilitating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to these circRNA‐driven inhibitory mechanisms, miR‑1304 also acts directly as an oncomiR in other settings. In African American breast cancer patients, miR‑1304‑3p is markedly upregulated and correlates with poor progression‑free survival. Functional studies indicate that elevated miR‑1304‑3p levels promote tumor progression by targeting the anti‑adipogenic gene GATA2, which in turn activates cancer‑associated adipocytes to supply lipids that support cancer cell growth. Notably, a single nucleotide polymorphism in the miR‑1304 stem‐loop region, with distinct allele frequencies between African and Caucasian Americans, enhances its maturation and may underlie ethnic disparities in breast cancer outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanhui Pan, Tingting Xu, Yuanzhi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.01.108"}], "href": "https://doi.org/10.1016/j.bbrc.2019.01.108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30709584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30709584"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guohua Liu, Hanbing Shi, Liling Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.213"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30954221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30954221"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenbo Du, Ding Li, Xiaomin Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1671857"}], "href": "https://doi.org/10.1080/21691401.2019.1671857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31701767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31701767"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Jin, Lisen Li, Tongtong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2019.152688"}], "href": "https://doi.org/10.1016/j.prp.2019.152688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31727503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31727503"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Minghui Chen, Xiaojuan Liu, Peng Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ_0074026 indicates unfavorable prognosis for patients with glioma and facilitates oncogenesis of tumor cells by targeting miR-1304 to modulate ERBB4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29347"}], "href": "https://doi.org/10.1002/jcp.29347"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31643077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31643077"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dan Zhao, Kerui Wu, Sambad Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-35305-2"}], "href": "https://doi.org/10.1038/s41467-022-35305-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36517516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36517516"}]}]}]}
Synonyms MIRN1304, HSA-MIR-1304
NCBI Gene ID 100302240
API
Download Associations
Predicted Functions View MIR1304's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1304's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1304's ARCHS4 Predicted Functions.

Functional Associations

MIR1304 has 1,206 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1304 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1304 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1304 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1304 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1304 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1304 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1304 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR1304 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1304 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1304 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR1304 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1304 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.