{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe diverse regulatory roles of miR‑1305 have been demonstrated in the differentiation of mesenchymal stem cells. In human synovium‑derived MSCs, lncRNA DANCR promotes chondrogenesis by down‑regulating miR‑1305, and forced expression of miR‑1305 counteracts DANCR‑induced cell proliferation and chondrogenic differentiation through modulation of the TGF‑β pathway member Smad4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, during osteogenic differentiation of human MSCs, the circular RNA circ_0076906 functions as a molecular sponge for miR‑1305, thereby controlling the expression of its target gene Osteoglycin (OGN) and promoting bone formation to alleviate osteoporosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn human pluripotent stem cells, including embryonic and induced pluripotent stem cells, miR‑1305 has emerged as a crucial regulator of cell fate. Its expression levels vary with cell cycle progression, where miR‑1305 overexpression induces differentiation, accelerates the G1/S transition, and increases apoptosis by targeting the transcription factor POLR3G. Conversely, down‑regulation of miR‑1305 helps maintain pluripotency and enhances cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in the context of cervical squamous cell carcinoma, miR‑1305 exhibits tumor‑suppressive properties. Here, a different circular RNA, circ_0072008, acts as a sponge for miR‑1305; the consequent reduction in miR‑1305 activity leads to increased expression of HELLS, a helicase linked to enhanced cell proliferation, migration, and invasion. These findings highlight the potential of targeting the miR‑1305/HELLS axis for therapeutic interventions in cervical cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Zhang, Xiangyi Sun, Shuo Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA DANCR regulates "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-1305"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Smad 4 axis to promote chondrogenic differentiation of human synovium-derived mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20170347"}], "href": "https://doi.org/10.1042/BSR20170347"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28674107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28674107"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Wen, Zhiping Guan, Binsheng Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2020.105719"}], "href": "https://doi.org/10.1016/j.biocel.2020.105719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32087327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32087327"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shibo Jin, Joseph Collin, Lili Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Role for miR-1305 in Regulation of Pluripotency-Differentiation Balance, Cell Cycle, and Apoptosis in Human Pluripotent Stem Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.2444"}], "href": "https://doi.org/10.1002/stem.2444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27339422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27339422"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chunhua He, Leng Liu "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2048945"}], "href": "https://doi.org/10.1080/21655979.2022.2048945"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35311456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35311456"}]}]}]}