MIR1306 Gene

HGNC Family Non-coding RNAs
Name microRNA 1306
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn oncological contexts, miR‑1306 exhibits context‐dependent functions. In hepatocellular carcinoma, the miR‑1306‑3p isoform is upregulated and functions as a tumor enhancer by targeting FBXL5, thereby promoting epithelial–mesenchymal transition and metastasis with its expression being further driven by FoxM1. Conversely, in melanoma cells, miR‑1306‑5p acts as a tumor suppressor; its overexpression inhibits proliferation, migration, and invasion by downregulating PCGF2, and its deregulation is also under investigation in the pathogenesis of acute myeloid leukemia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn studies examining cellular stress responses and tissue injury, miR‑1306‑5p plays a protective role in neuronal cells exposed to oxygen–glucose deprivation/reoxygenation, where its downregulation is associated with increased cell death; restoration of its expression mitigates injury through direct targeting of the pro‐apoptotic protein BIK. Similarly, in sepsis‐induced intestinal barrier dysfunction, miR‑1306‑5p targets PLK1, and its sequestration by the long non‑coding RNA DANCR leads to decreased epithelial apoptosis and improved mucosal integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cell survival and oncogenic processes, miR‑1306‑5p is also implicated in the regulation of other physiological processes. In vascular smooth muscle cells exposed to oxidative stress (simulating atherosclerotic conditions), miR‑1306‑5p modulates proliferation, migration, and invasion through its targeting of SIRT7. In the context of amelogenesis imperfecta, miR‑1306‑5p has been identified as a regulatory molecule that influences ameloblast differentiation by modulating genes critical for enamel formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhi-Jiang He, Wen Li, Hua Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1306-3p targets FBXL5 to promote metastasis of hepatocellular carcinoma through suppressing snail degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.09.059"}], "href": "https://doi.org/10.1016/j.bbrc.2018.09.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30219228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30219228"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kai Wang, Min Li, Hongyan Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLCO4A1-AS1 triggers the malignant behaviours of melanoma cells via sponging miR-1306-5p to enhance PCGF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/exd.14577"}], "href": "https://doi.org/10.1111/exd.14577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35427425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35427425"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiang Gao, Sumei Fan, Xiaolei Zhang "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2022.106906"}], "href": "https://doi.org/10.1016/j.leukres.2022.106906"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35780573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35780573"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xuelin Chen, Caixia Li, Jianghao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-1306-5p decreases cerebral ischemia/reperfusion injury "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " by targeting BIK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2019.1654846"}], "href": "https://doi.org/10.1080/09168451.2019.1654846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31460837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31460837"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhen Wang, Changshun Zhong, Yingya Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DANCR improves the dysfunction of the intestinal barrier and alleviates epithelial injury by targeting the miR-1306-5p/PLK1 axis in sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11633"}], "href": "https://doi.org/10.1002/cbin.11633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34003569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34003569"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jianghua Zheng, Qiang Tan, Hang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA‑SNHG7‑003 inhibits the proliferation, migration and invasion of vascular smooth muscle cells by targeting the miR‑1306‑5p/SIRT7 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2020.4821"}], "href": "https://doi.org/10.3892/ijmm.2020.4821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33416100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33416100"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hiroki Yoshioka, Yin-Ying Wang, Akiko Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-1306-5p, miR-3195, and miR-3914 Inhibits Ameloblast Differentiation through Suppression of Genes Associated with Human Amelogenesis Imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22042202"}], "href": "https://doi.org/10.3390/ijms22042202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33672174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33672174"}]}]}]}
Synonyms HSA-MIR-1306, MIR-1306, MIRN1306
NCBI Gene ID 100302197
API
Download Associations
Predicted Functions View MIR1306's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1306's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1306's ARCHS4 Predicted Functions.

Functional Associations

MIR1306 has 1,551 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR1306 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1306 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1306 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1306 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1306 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1306 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1306 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1306 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR1306 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1306 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR1306 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1306 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1306 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR1306 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1306 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR1306 protein from the Wikipathways Pathways 2014 dataset.