{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‑1307 plays a multifaceted oncogenic role in several cancer types. In prostate cancer, miR‑1307 is overexpressed and promotes cell proliferation and tumorigenesis by directly targeting FOXO3A and reducing the levels of cell cycle inhibitors p21 and p27."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, increased levels of miR‑1307‑3p enhance proliferation, migration, and invasion through suppression of the tumor suppressor DAB2IP, with hypoxia further upregulating miR‑1307‑3p via a HIF‑1α‐mediated feedback loop."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In colorectal cancer, a single nucleotide polymorphism (rs7911488) in the terminal loop of pre‑miR‑1307 is associated with altered miR‑1307 expression that modulates apoptosis—reduced miR‑1307 correlates with Bcl2 overexpression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", whereas the T‑allelic variant drives miR‑1307 overexpression, which in turn downregulates PRRX1 to enhance proliferative and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Exosomal miR‑1307 further contributes to osteosarcoma progression by targeting AGAP1, thereby promoting proliferation, migration, and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in pancreatic ductal adenocarcinoma, modulation of miR‑1307 levels affects chemosensitivity through its binding to CLIC5 mRNA, influencing apoptosis and DNA damage accumulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in ovarian cancer, functional studies indicate that miR‑1307 participates in the development of chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOutside of its roles in tumor biology, miR‑1307 has been implicated in immune modulation, fibrotic disease, and virus–host interactions. Genetic polymorphisms of miR‑1307 are associated with susceptibility and clinical outcomes in systemic lupus erythematosus"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", while in chronic obstructive pulmonary disease, upregulation of miR‑1307‑5p in lung fibroblasts promotes TGF‑β–induced myofibroblast activation via targeting FBXL16 and modulating HIF1α degradation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In addition, conserved stem–loop elements in the SARS‑CoV‑2 genome have been shown to interact with host miR‑1307‑3p; notably, the viral s2m element binds to miR‑1307‑3p, and mutations in this region in the Delta variant alter this interaction, suggesting potential consequences for viral replication and the host immune response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaodi Qiu, Ying Dou "}, {"type": "b", "children": [{"type": "t", "text": "miR-1307 promotes the proliferation of prostate cancer by targeting FOXO3A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2016.11.120"}], "href": "https://doi.org/10.1016/j.biopha.2016.11.120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28122308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28122308"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuangjiang Chen, Liang Wang, Bowen Yao, et al. 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