{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐130a has emerged as a versatile regulator of normal cellular differentiation and metabolic homeostasis. In adipose tissue, elevated miR‐130a levels suppress the differentiation of preadipocytes into adipocytes by directly targeting the key adipogenic transcription factor PPARγ, with perturbations in this regulation associated with obesity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hematopoietic cells, miR‐130a modulates cell cycle progression and responsiveness to transforming growth factor–β (TGF‐β) by downregulating Smad4 expression, thereby controlling granulocytic cell expansion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in endothelial progenitor cells and the liver, miR‐130a influences lipid metabolism and differentiation by intersecting with pathways involving ERK/VEGF and TGF‐β receptor signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while in myocardial cells altered miR‐130a levels via regulatory loops with long noncoding RNAs such as XIST contribute to post‐infarction remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, in models of non‐alcoholic fatty liver disease, miR‐130a interfaces with lipogenic processes by modulating the expression of metabolic regulators like PPARγ, underscoring its role in maintaining hepatic metabolic equilibrium."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer, miR‐130a exerts complex, context‐dependent effects that can be either tumor suppressive or oncogenic. In non–small cell lung cancer, reduced levels of miR‐130a are linked to enhanced cell survival and resistance to apoptosis by indirectly affecting MET‐dependent signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In chronic lymphocytic leukemia, re‐expression of miR‐130a inhibits autophagy by targeting genes such as ATG2B and DICER1, thereby modulating tumor cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In ovarian and cervical cancers, high miR‐130a levels contribute to chemoresistance by upregulating MDR1/P‐glycoprotein or by targeting tumor suppressors like RUNX3 and XIAP."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": " In breast cancer, miR‐130a functions as a tumor suppressor by directly downregulating oncogenic targets such as RAB5A, and its circulating levels further serve as potential biomarkers for disease subtype and prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Similarly, in ovarian carcinoma and gastric cancer, miR‐130a contributes to aggressive phenotypes and chemoresistance by modulating key pathways including those governed by PTEN and Wnt/β‐catenin."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": " In addition, positive feedback regulation of YAP signaling via miR‐130a repression of VGLL4 has been implicated in organ size control and tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", while aberrant miR‐130a expression further promotes chemoresistant and metastatic behaviors in hepatocellular carcinoma and osteosarcoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Epigenetic silencing of miR‐130a in prostate cancer also points to its tumor‐suppressive role in this context"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ", whereas its overexpression induces oncogenic mTOR activation in other ovarian cancer models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " In triple‐negative breast cancer, miR‐130a directly targets FOSL1 to curtail migration and invasion, and reduced miR‐130a levels in circulating exosomes have been linked with advanced tumor stage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": " Finally, analysis of the tumor microenvironment under chemoresistant conditions further supports a role for miR‐130a in modulating drug response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond development and oncogenesis, miR‐130a plays a pivotal role in modulating inflammatory responses, fibrogenesis, and antiviral defense. 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