{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐130b (miR‑130b) plays a versatile role in tumor progression by modulating epithelial–mesenchymal transition (EMT), invasion and metastasis in a context‐dependent manner. In endometrial cancer cells harboring mutant p53, for example, miR‑130b is transcriptionally repressed, thereby relieving inhibition of the ZEB1 EMT driver and promoting invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In HTLV‑1–transformed T cells its elevated expression directly targets the tumor suppressor TP53INP1, favoring cell survival and expansion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In colorectal cancer, increased miR‑130b levels suppress PTEN expression leading to the over‐expression of the immune checkpoint molecule B7‑H1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and in other colorectal tumor models, miR‑130b targets peroxisome proliferator‑activated receptor γ (PPARγ) to deregulate key mediators of EMT and angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In breast cancer, high miR‑130b contributes to drug resistance and invasive behavior"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in hepatocellular carcinoma elevated miR‑130b associates with dedifferentiated, aggressive tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Likewise, in endometrial cancer models with DICER1 dysfunction, miR‑130b up‐regulation further promotes EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In contrast, in prostate cancer certain studies indicate that restoration of miR‑130b suppresses cell migration and invasion through direct targeting of matrix metalloproteinase‑2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and in a separate colorectal cancer investigation, reduced miR‑130b levels were linked to increased integrin β1 expression and enhanced cell motility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its impact on metastatic traits, miR‑130b also regulates cell proliferation and chemoresponsiveness. In pancreatic cancer, miR‑130b is significantly downregulated and its enforced expression suppresses STAT3 activity, thereby inducing apoptosis and cell cycle arrest."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In pituitary adenomas, overexpression of miR‑130b arrests cell cycle progression via targeting cyclin A2, limiting proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In multiple myeloma, upregulation of miR‑130b decreases glucocorticoid receptor levels, dampening the cellular response to glucocorticoid‐induced apoptosis and contributing to drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Furthermore, miR‑130b has been implicated in the regulation of hepatic drug metabolism, where its elevated expression in cholestatic liver models represses key nuclear receptors and cytochrome P450 enzymes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In thyroid cancer, deregulated miR‑130b mediated by T3/TR signaling pathways has also been observed"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", while in ovarian carcinoma, heightened miR‑130b expression in drug‐resistant cells coincides with modulation of multidrug resistance genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, in endocrine settings such as polycystic ovary syndrome (PCOS), reduced levels of miR‑130b in ovarian theca cells correlate with increased expression of DENND1A variant 2 and consequent hyperandrogenism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nmiR‑130b also contributes to the pathogenesis of non‑malignant and inflammatory disorders, as well as serving as a circulating biomarker in diverse disease settings. In renal pathologies, diminished circulating miR‑130b levels associate with increased proteinuria and tubulointerstitial fibrosis in diabetic nephropathy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", whereas in lupus nephritis, elevated serum miR‑130b‑3p facilitates epithelial–mesenchymal transition in tubular cells via ERBB2IP suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " In sarcomas, such as Ewing sarcoma, increased miR‑130b enhances metastatic potential by targeting ARHGAP1 and activating CDC42 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Moreover, in prostate cancer, a c‑Met/miR‑130b axis has been shown to promote castration resistance by inhibiting androgen receptor expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ", while in bladder transitional cell carcinoma, miR‑130b enhances NF‑κB signaling through CYLD downregulation, contributing to tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": " In non‑small cell lung cancer, high miR‑130b levels promote invasion via targeting tissue inhibitor of metalloproteinase‑2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": ", and in osteosarcoma, miR‑130b activates Wnt signaling by repressing NKD2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " Additionally, the detection of miR‑130b in exosomes has been proposed as a prognostic biomarker in aggressive medulloblastoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": "and as part of a three‑miRNA signature predictive of outcome in clear cell renal cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "P Dong, M Karaayvaz, N Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.334"}], "href": "https://doi.org/10.1038/onc.2012.334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22847613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22847613"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Man Lung Yeung, Jun-ichirou Yasunaga, Yamina Bennasser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-0769"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-0769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18974142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18974142"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianjie Zhu, Lanxin Chen, Lingting Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humimm.2014.01.006"}], "href": "https://doi.org/10.1016/j.humimm.2014.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24468585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24468585"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tommaso Colangelo, Alessandra Fucci, Carolina Votino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.13998"}], "href": "https://doi.org/10.1593/neo.13998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24027433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24027433"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuan Miao, Wei Zheng, Nana Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep41942"}], "href": "https://doi.org/10.1038/srep41942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28165066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28165066"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kangsheng Tu, Xin Zheng, Changwei Dou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-130b promotes cell aggressiveness by inhibiting peroxisome proliferator-activated receptor gamma in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms151120486"}], "href": "https://doi.org/10.3390/ijms151120486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25387077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25387077"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bi-Lan Li, Cong Lu, Wen Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-130b is an EMT-related microRNA that targets DICER1 for aggression in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-013-0484-0"}], "href": "https://doi.org/10.1007/s12032-013-0484-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23392577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23392577"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qin Chen, Xian Zhao, Hailong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-130b suppresses prostate cancer metastasis through down-regulation of MMP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22204"}], "href": "https://doi.org/10.1002/mc.22204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25154741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25154741"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yanyang Zhao, Gang Miao, Yao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin β1 [corrected]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0087938"}], "href": "https://doi.org/10.1371/journal.pone.0087938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24498407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24498407"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gang Zhao, Jun-gang Zhang, Ying Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0073803"}], "href": "https://doi.org/10.1371/journal.pone.0073803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24040078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24040078"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Vincenza Leone, Concetta Langella, Daniela D'Angelo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mir-23b and miR-130b expression is downregulated in pituitary adenomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2014.03.002"}], "href": "https://doi.org/10.1016/j.mce.2014.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24681352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24681352"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Michael A Tessel, Ashley L Benham, Nancy L Krett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for microRNAs in regulating glucocorticoid response and resistance in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12672-011-0072-8"}], "href": "https://doi.org/10.1007/s12672-011-0072-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21761344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21761344"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jessica K Rieger, Sandra Reutter, Ute Hofmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.114.062844"}], "href": "https://doi.org/10.1124/dmd.114.062844"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25802328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25802328"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yang-Hsiang Lin, Meng-Han Wu, Chia-Jung Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repression of microRNA-130b by thyroid hormone enhances cell motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2014.12.035"}], "href": "https://doi.org/10.1016/j.jhep.2014.12.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25617495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25617495"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Can Zong, Jun Wang, Tie-Mei Shi "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 130b enhances drug resistance in human ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2520-x"}], "href": "https://doi.org/10.1007/s13277-014-2520-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25155039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25155039"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Li-Ya Chiu, Priya S Kishnani, Tzu-Po Chuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of differentially expressed microRNAs in human hepatocellular adenoma associated with type I glycogen storage disease: a potential utility as biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00535-013-0890-2"}], "href": "https://doi.org/10.1007/s00535-013-0890-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24129885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24129885"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jan M McAllister, Angela X Han, Bhavi P Modi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen Biosynthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2019-00013"}], "href": "https://doi.org/10.1210/en.2019-00013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31184707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31184707"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaoyan Bai, Jian Geng, Zhanmei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep20475"}], "href": "https://doi.org/10.1038/srep20475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26837280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26837280"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Chuan Lv, Yue-Hong Zhou, Can Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The changes in miR-130b levels in human serum and the correlation with the severity of diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Metab Res Rev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dmrr.2659"}], "href": "https://doi.org/10.1002/dmrr.2659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25952368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25952368"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wanpeng Wang, Shan Mou, Ling Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of Serum MiR-130b-3p Level is Associated with Renal Damage in Early Lupus Nephritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep12644"}], "href": "https://doi.org/10.1038/srep12644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26316103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26316103"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Laura Satterfield, Ryan Shuck, Lyazat Kurenbekova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.30909"}], "href": "https://doi.org/10.1002/ijc.30909"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28748534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28748534"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "João Ramalho-Carvalho, Inês Graça, Antonio Gomez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-017-0415-1"}], "href": "https://doi.org/10.1186/s13045-017-0415-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28166834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28166834"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "A Cannistraci, G Federici, A Addario, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.505"}], "href": "https://doi.org/10.1038/onc.2016.505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28192399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28192399"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiaolu Cui, Chuize Kong, Yuyan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-κB and sustains NF-κB activation by decreasing Cylindromatosis expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10423"}], "href": "https://doi.org/10.18632/oncotarget.10423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27391066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27391066"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Takayuki Hirono, Kentaro Jingushi, Toshiyuki Nagata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-130b functions as an oncomiRNA in non-small cell lung cancer by targeting tissue inhibitor of metalloproteinase-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-43355-8"}], "href": "https://doi.org/10.1038/s41598-019-43355-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31061410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31061410"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Zhi Li, Youjun Li, Nan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.02.050"}], "href": "https://doi.org/10.1016/j.bbrc.2016.02.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26902120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26902120"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Saihua Huang, Ping Xue, Xiao Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2621-y"}], "href": "https://doi.org/10.1038/s41419-020-2621-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32483145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32483145"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yongwen Luo, Liang Chen, Gang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a three-miRNA signature as a novel potential prognostic biomarker in patients with clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28648"}], "href": "https://doi.org/10.1002/jcb.28648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30957284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30957284"}]}]}]}