{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that miR‑1321 plays a pivotal role in ovarian cancer progression. In one study, upregulated lncRNA NEAT1 was shown to sponge miR‑1321, thereby alleviating its inhibitory effect on tight junction protein 3 (TJP3). The resultant overexpression of TJP3 was associated with enhanced cell proliferation, invasion, migration, and epithelial‑mesenchymal transition (EMT) in ovarian cancer cells, indicating that the sequestration of miR‑1321 by NEAT1 contributes to cancer metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a different study focusing on non‑small cell lung cancer (NSCLC), miR‑1321 was identified as a tumor suppressor that directly targets cell division cycle 20 (CDC20). Elevated CDC20 levels, which correlated with poor prognoses in NSCLC patients, were effectively reduced by miR‑1321, along with miR‑7515, leading to decreased proliferation, migration, and invasion, and increased apoptosis of NSCLC cells. These findings underscore the anti‑tumor effects of miR‑1321 in lung cancer by modulating CDC20 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, the studies highlight the context‑dependent functions of miR‑1321 in cancer. In ovarian cancer, miR‑1321 acts as a negative regulator of TJP3, with its downregulation via NEAT1 sponging facilitating metastasis, whereas in NSCLC, miR‑1321 suppresses tumor progression by targeting CDC20. These insights not only delineate the multifaceted roles of miR‑1321 in different tumor types but also suggest its potential as a diagnostic biomarker and therapeutic target in oncology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Min Luo, Lei Zhang, Hongying Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA NEAT1 promotes ovarian cancer cell invasion and migration by interacting with miR‑1321 and regulating tight junction protein 3 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11428"}], "href": "https://doi.org/10.3892/mmr.2020.11428"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32945443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32945443"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hao Hu, Fang-Fang Tou, Wei-Min Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1321 and microRNA-7515 contribute to the progression of non-small cell lung cancer by targeting CDC20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12500"}], "href": "https://doi.org/10.1002/kjm2.12500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35050556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35050556"}]}]}]}