MIR1322 Gene

HGNC Family Non-coding RNAs
Name microRNA 1322
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐1322 is emerging as a versatile post‐transcriptional regulator with context‐dependent functions in cancer. In esophageal squamous cell carcinoma, miR‐1322 acts in an allele‐specific manner to down‐regulate the tumor suppressor gene ECRG2 when bound to its 3′‐UTR, and its elevated expression in tumor tissue and serum suggests its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, bioinformatic analyses reveal that miR‐1322 possesses an unusually high number of binding sites across coding sequences of over a thousand genes – many encoding transcription factors – suggesting that its regulatory impact could be broad and orchestrated through arrangement of binding sites within coding regions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, miR‐1322 modulates key metabolic processes, as illustrated by its ability to bind the 3′‐UTR of the carbohydrate response element‐binding protein (ChREBP) in an allele‐dependent fashion, thereby down‐regulating ChREBP and affecting downstream lipid synthesis and glucose homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, Fusobacterium nucleatum infection suppresses miR‐1322 via activation of the NF‐κB pathway, which in turn derepresses the chemokine CCL20. This miR‐1322/CCL20 axis contributes to enhanced tumor metastasis through promotion of M2 macrophage polarization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tengfei Zhang, Dan Zhao, Qiming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.21880"}], "href": "https://doi.org/10.1002/mc.21880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22315007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22315007"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Raigul Niyazova, Olga Berillo, Shara Atambayeva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1322 Binding Sites in Paralogous and Orthologous Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/962637"}], "href": "https://doi.org/10.1155/2015/962637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26114118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26114118"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ying Zhang, Sen-Lin Hu, Dong Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1322 regulates ChREBP expression via binding a 3'-UTR variant (rs1051943)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13805"}], "href": "https://doi.org/10.1111/jcmm.13805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30079502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30079502"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chaochao Xu, Lina Fan, Yifeng Lin, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Fusobacterium nucleatum"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut Microbes (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/19490976.2021.1980347"}], "href": "https://doi.org/10.1080/19490976.2021.1980347"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34632963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34632963"}]}]}]}
Synonyms HSA-MIR-1322, MIRN1322
NCBI Gene ID 100302166
API
Download Associations
Predicted Functions View MIR1322's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1322's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1322's ARCHS4 Predicted Functions.

Functional Associations

MIR1322 has 585 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR1322 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1322 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1322 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1322 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1322 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1322 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1322 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1322 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1322 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1322 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1322 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1322 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1322 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.