MIR1323 Gene

HGNC Family Non-coding RNAs
Name microRNA 1323
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In lung cancer cells, its overexpression enhances radioresistance by directly binding to the 3′UTR of PRKDC, which encodes DNA‐dependent protein kinase critical for DNA repair processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cervical cancer cells, miR‐1323—delivered via cancer‐associated fibroblast exosomes—is upregulated and promotes cell proliferation, migration, invasion, and resistance to radiotherapy by targeting poly(A)-binding protein nuclear 1 (PABPN1), thereby modulating the IGF2BP1/GSK-3β/Wnt/β-catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In non‐small cell lung cancer, miR‐1323 interacts with programmed cell death 4 (PDCD4) and its inhibition via circRNA sponging reduces cisplatin resistance, suggesting that active miR‐1323 contributes to chemoresistance and malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, miR‐1323 appears to function as a tumor suppressor in other cancer contexts. In breast cancer, its levels are decreased in tissues and patient serum, and this downregulation is associated with lymph node metastasis and an advanced clinical stage. Loss of miR‐1323 permits the overexpression of its direct target, TPD52, thereby accelerating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in colorectal cancer with hepatic metastases, sponging of miR‐132-3p by LINC00858 results in upregulation of IGF2BP1, which facilitates tumor growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOutside of cancer, miR‐1323 plays significant roles in modulating responses to cellular stress and disease pathology. In renal ischemic injury, oxidative stress induces miR‐132-3p, which directly targets Sirt1 and promotes tubular cell apoptosis, thereby exacerbating acute kidney injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In osteoarthritis, lncRNA ZFAS1 sequesters miR‐1323, relieving its repression of Nrf2 and affecting the anti-oxidative signaling pathway; this axis influences chondrocyte proliferation, oxidative stress, and inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Furthermore, in endometriosis, miR‐1323 is bound by lncRNA C8orf49, which in turn regulates the expression of PTEN and FZD4, thereby promoting endometrial stromal cell proliferation and lesion growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong Li, Wei Han, Ting-Ting Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of microRNA-1323 restores sensitivity to radiation by suppression of PRKDC activity in radiation-resistant lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.3884"}], "href": "https://doi.org/10.3892/or.2015.3884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25823795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25823795"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fang Fang, Chunfeng Guo, Weinan Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-Mediated Transfer of miR-1323 from Cancer-Associated Fibroblasts Confers Radioresistance of C33A Cells by Targeting PABPN1 and Activating Wnt/β-Catenin Signaling Pathway in Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-021-00820-y"}], "href": "https://doi.org/10.1007/s43032-021-00820-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35334101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35334101"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Changyu Zhu, Xiaolei Jiang, Hua Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0030998 Restrains Cisplatin Resistance Through Mediating miR-1323/PDCD4 Axis in Non-small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-022-10220-9"}], "href": "https://doi.org/10.1007/s10528-022-10220-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35460386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35460386"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuanying Xu, Meiyan Liu "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1323 downregulation promotes migration and invasion of breast cancer cells by targeting tumour protein D52."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvaa035"}], "href": "https://doi.org/10.1093/jb/mvaa035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32211853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32211853"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Peng Sun, Yusong Luan, Xuhao Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00858 facilitates formation of hepatic metastases from colorectal cancer via regulating the miR-132-3p/IGF2BP1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2022-0328"}], "href": "https://doi.org/10.1515/hsz-2022-0328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36857196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36857196"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chenglong Li, Shangting Han, Jiefu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2023.110801"}], "href": "https://doi.org/10.1016/j.cellsig.2023.110801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37433399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37433399"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yanglin Gu, Guangchang Wang, Huazhong Xu "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZNFX1 antisense 1 (ZFAS1) suppresses anti-oxidative stress in chondrocytes during osteoarthritis by sponging microRNA-1323."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2074770"}], "href": "https://doi.org/10.1080/21655979.2022.2074770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35635081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35635081"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Meichen Yin, Jianzhang Wang, Xue Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non coding RNA, C8orf49, a novel diagnostic and prognostic biomarker, enhances PTEN/FZD4-mediated cell growth and metastasis by sponging miR-1323 in endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2023.112040"}], "href": "https://doi.org/10.1016/j.mce.2023.112040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37557978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37557978"}]}]}]}
Synonyms MIRN1323, MIR-1323, HSA-MIR-1323
NCBI Gene ID 100302255
API
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Predicted Functions View MIR1323's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1323's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1323's ARCHS4 Predicted Functions.

Functional Associations

MIR1323 has 224 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR1323 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1323 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1323 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1323 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1323 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1323 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1323 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1323 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1323 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1323 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1323 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.