MIR1324 Gene

HGNC Family Non-coding RNAs
Name microRNA 1324
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that microRNA‐1324 plays a crucial regulatory role in cellular processes by interacting with circular RNAs. In Hirschsprung disease, for instance, circ‐PRKCI was found to function as a molecular sponge for miR‑1324, leading to the upregulation of PLCB1. This interaction consequently promoted cell proliferation and migration, suggesting that the miR‑1324/PLCB1 axis is important in modulating neural crest‐derived cell behavior during disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, investigations into gastric cancer have aimed to elucidate the expression levels and potential molecular mechanisms of miR‑1324. Although the detailed downstream targets remain to be fully clarified, the altered levels of miR‑1324 in gastric cancer tissues imply that this microRNA may serve as a promising biomarker and therapeutic target, offering new insights into tumorigenesis and treatment strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of prostate cancer, particularly castration‑resistant prostate cancer (CRPC), another circRNA—hsa_circ_0001610—has been identified as exerting its oncogenic effects by sponging miR‑1324. By sequestering miR‑1324, hsa_circ_0001610 relieves the repressive effect of miR‑1324 on its target gene PTK6, thereby enhancing PTK6 expression. This molecular interaction promotes tumor cell proliferation, migration, and resistance to enzalutamide, underscoring the potential of targeting the hsa_circ_0001610/miR‑1324/PTK6 axis for therapeutic intervention in advanced prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lingling Zhou, Yang Li, Weiwei Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2018.1480210"}], "href": "https://doi.org/10.1080/15384101.2018.1480210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29895226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29895226"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X-Y Zhang, Y-Y Xu, W-Y Chen "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1324 inhibits cell proliferative ability and invasiveness by targeting MECP2 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21165"}], "href": "https://doi.org/10.26355/eurrev_202005_21165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32432740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32432740"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yunpeng Li, Aoyu Fan, Yunyan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0001610 promotes prostate cancer progression by sponging miR-1324 and upregulating PTK6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2024.148818"}], "href": "https://doi.org/10.1016/j.gene.2024.148818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39098513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39098513"}]}]}]}
Synonyms MIRN1324, HSA-MIR-1324
NCBI Gene ID 100302212
API
Download Associations
Predicted Functions View MIR1324's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1324's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1324's ARCHS4 Predicted Functions.

Functional Associations

MIR1324 has 470 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1324 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1324 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1324 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1324 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1324 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1324 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1324 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1324 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1324 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1324 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1324 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1324 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.