{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-133a (MIR133A1) is a highly conserved, muscle‐enriched microRNA that plays critical roles in cardiac and skeletal muscle function. In the heart and developing muscle, miR-133a is dynamically regulated during myoblast differentiation and in response to ischemic or hypoxic stress, where it attenuates cardiomyocyte apoptosis and modulates ion channel expression and fibrotic remodeling. Its altered expression in acute myocardial infarction and age–associated atrial dysfunction further supports its use as a sensitive circulating biomarker and as an epigenetic regulator of cardiac hypertrophy and fibrogenic pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its essential roles in muscle physiology, miR-133a functions as a potent tumor suppressor in a wide array of human malignancies. Numerous studies have documented its downregulation in cancers of the esophagus, prostate, lung, colorectum, bladder, pancreas, ovary, glioma, head and neck, and bone. Restoration of miR-133a in tumor cells leads to marked inhibition of cell proliferation, migration, and invasion, while inducing cell cycle arrest and apoptosis. These tumor-suppressive effects are mediated through the direct targeting of multiple oncogenic transcripts—including FSCN1, GSTP1, ARPC5, LASP1, RFFL, HLA-G, IGF1R, TGFBR1, EGFR, MSN, and certain matrix metalloproteinases—thereby modulating key signaling pathways such as MAPK and p53 networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in muscle homeostasis and tumor suppression, miR-133a is implicated in other pathological settings. In postmenopausal osteoporosis, elevated circulating miR-133a levels correlate with reduced bone mineral density and promote osteoclast differentiation. Furthermore, aberrant miR-133a expression in trophoblastic cells has been shown to disrupt immune tolerance by targeting HLA-G, thereby contributing to recurrent spontaneous abortion. Emerging data from gastric cancer studies also underscore the multifaceted impact of miR-133a across diverse tissue types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Emanuela Bostjancic, Nina Zidar, Damjan Glavac "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA microarray expression profiling in human myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/DMA-2009-0671"}], "href": "https://doi.org/10.3233/DMA-2009-0671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20075508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20075508"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yasuhide Kuwabara, Koh Ono, Takahiro Horie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Cardiovasc Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCGENETICS.110.958975"}], "href": "https://doi.org/10.1161/CIRCGENETICS.110.958975"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21642241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21642241"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Andrie Koutsoulidou, Nikolaos P Mastroyiannopoulos, Denis Furling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Dev Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-213X-11-34"}], "href": "https://doi.org/10.1186/1471-213X-11-34"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21645416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21645416"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Feng Wang, Guangwen Long, Chunxia Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma microRNA-133a is a new marker for both acute myocardial infarction and underlying coronary artery stenosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1479-5876-11-222"}], "href": "https://doi.org/10.1186/1479-5876-11-222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24053180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24053180"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "An-Ying Li, Qiong Yang, Kan Yang "}, {"type": "b", "children": [{"type": "t", "text": "miR-133a mediates the hypoxia-induced apoptosis by inhibiting TAGLN2 expression in cardiac myocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-014-2273-2"}], "href": "https://doi.org/10.1007/s11010-014-2273-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25421410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25421410"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yao-Dong Li, Yi-Fan Hong, Yueerguli Yusufuaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.3831"}], "href": "https://doi.org/10.3892/mmr.2015.3831"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26005035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26005035"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ludivine Renaud, Lillianne G Harris, Santhosh K Mani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Heart Fail (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCHEARTFAILURE.114.001781"}], "href": "https://doi.org/10.1161/CIRCHEARTFAILURE.114.001781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26371176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26371176"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Peng Wei, Yan Xie, Peter W Abel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1873-x"}], "href": "https://doi.org/10.1038/s41419-019-1873-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31511493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31511493"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Masayuki Kano, Naohiko Seki, Naoko Kikkawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25284"}], "href": "https://doi.org/10.1002/ijc.25284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21351259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21351259"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yousuke Uchida, Takeshi Chiyomaru, Hideki Enokida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-133a induces apoptosis through direct regulation of GSTP1 in bladder cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urol Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.urolonc.2010.09.017"}], "href": "https://doi.org/10.1016/j.urolonc.2010.09.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21396852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21396852"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yasumitsu Moriya, Nijiro Nohata, Takashi Kinoshita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2011.126"}], "href": "https://doi.org/10.1038/jhg.2011.126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22089643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22089643"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nijiro Nohata, Toyoyuki Hanazawa, Hideki Enokida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.424"}], "href": "https://doi.org/10.18632/oncotarget.424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22308266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22308266"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Takashi Kinoshita, Nijiro Nohata, Haruko Watanabe-Takano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2012.1390"}], "href": "https://doi.org/10.3892/ijo.2012.1390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22378351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22378351"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jun Tao, Deyao Wu, Bin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2012.1711"}], "href": "https://doi.org/10.3892/or.2012.1711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22407299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22407299"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yunfeng Zhou, Deyao Wu, Jun Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Urol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00365599.2012.748821"}], "href": "https://doi.org/10.3109/00365599.2012.748821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23206218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23206218"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yujuan Dong, Junhong Zhao, Chung-Wah Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor functions of miR-133a in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-13-0061"}], "href": "https://doi.org/10.1158/1541-7786.MCR-13-0061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23723074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23723074"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Fang Ji, Hao Zhang, Yang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2013.05.020"}], "href": "https://doi.org/10.1016/j.bone.2013.05.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23756231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23756231"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Meng Xu, Yu-Zhou Wang "}, {"type": "b", "children": [{"type": "t", "text": "miR‑133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP‑14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2013.2548"}], "href": "https://doi.org/10.3892/or.2013.2548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23783274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23783274"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hui Wang, Hongying An, Bin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2013.07.149"}], "href": "https://doi.org/10.1016/j.ejca.2013.07.149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23968734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23968734"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Sayantani Bandyopadhyay, Troy Lane, Rajanbabu Venugopal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.08.056"}], "href": "https://doi.org/10.1016/j.bbrc.2013.08.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23988448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23988448"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jinling Guo, Bairong Xia, Fanling Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-133a suppresses ovarian cancer cell proliferation by directly targeting insulin-like growth factor 1 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-013-1215-z"}], "href": "https://doi.org/10.1007/s13277-013-1215-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24127040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24127040"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lu-Kai Wang, Tzu-Hung Hsiao, Tse-Ming Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0096765"}], "href": "https://doi.org/10.1371/journal.pone.0096765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24816813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24816813"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hao Yu, Yinhui Lu, Zhaofa Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-133: expression, function and therapeutic potential in muscle diseases and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Drug Targets (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1389450115666140627104151"}], "href": "https://doi.org/10.2174/1389450115666140627104151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24975488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24975488"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yong Qin, Xiaoyan Dang, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-133a functions as a tumor suppressor and directly targets FSCN1 in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504014X14024160459122"}], "href": "https://doi.org/10.3727/096504014X14024160459122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25198665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25198665"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hiroko Mataki, Hideki Enokida, Takeshi Chiyomaru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2014.111"}], "href": "https://doi.org/10.1038/jhg.2014.111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25518741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25518741"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Claudia Bang, Charalambos Antoniades, Alexios S Antonopoulos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intercellular communication lessons in heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Heart Fail (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ejhf.399"}], "href": "https://doi.org/10.1002/ejhf.399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26398116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26398116"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Guangnan Chen, Tingting Fang, Zhongming Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-133a Inhibits Osteosarcoma Cells Proliferation and Invasion via Targeting IGF-1R."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000438653"}], "href": "https://doi.org/10.1159/000438653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26845446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26845446"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Qi Yang, Yang Yu, Ziqian Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA PVT1 promotes cell proliferation and invasion through regulating miR-133a in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.06.112"}], "href": "https://doi.org/10.1016/j.biopha.2018.06.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29957467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29957467"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Chuanwei Li, Fang Pei, Xiaoshan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinbiochem.2012.04.013"}], "href": "https://doi.org/10.1016/j.clinbiochem.2012.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22713968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22713968"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Hongqiu Li, Zhe Wang, Qin Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma miRNA levels correlate with sensitivity to bone mineral density in postmenopausal osteoporosis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/1354750X.2014.935957"}], "href": "https://doi.org/10.3109/1354750X.2014.935957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25231354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25231354"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yu Gong, Jun Ren, Kun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v21.i10.2949"}], "href": "https://doi.org/10.3748/wjg.v21.i10.2949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25780292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25780292"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Zhongqi Li, Wenzhi Zhang, Yan Huang "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmy006"}], "href": "https://doi.org/10.1093/abbs/gmy006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29425279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29425279"}]}]}]}