MIR133A2 Gene

HGNC Family Non-coding RNAs
Name microRNA 133a-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In these contexts, restoration of MIR133A2 levels suppresses cell proliferation, invasion, and metastatic spread, whereas its epigenetic silencing (for instance via aberrant promoter methylation) or sequestration by oncogenic long non‐coding RNAs contributes to tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic roles, MIR133A2 is pivotal in the regulation of cardiovascular and other non‐malignant processes. In myocardial infarction and in conditions of atrial fibrillation, its expression in heart tissue is closely linked to proper electrical conduction and contractile function. In primary human lung fibroblasts, MIR133A2 is induced by transforming growth factor–β1 and then acts as an anti‐fibrotic factor by repressing profibrogenic genes, thus mediating a negative feedback loop to limit myofibroblast differentiation. In endothelial cells, MIR133A2 (especially the 3p strand) directly modulates the levels of key proteins such as aquaporin‑1, which contributes to endothelial migration, tube formation, and overall angiogenic capacity. Moreover, its circulating levels have been associated with biomarkers of vascular injury and early end‐organ damage in conditions like hypertension, further supporting a role in cardiovascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yasumitsu Moriya, Nijiro Nohata, Takashi Kinoshita, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by reducing pro-angiogenic but increasing anti-angiogenic gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-19172-x"}], "href": "https://doi.org/10.1038/s41598-022-19172-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36042288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36042288"}]}]}]}
Synonyms MIRN133A2, MIR-133A-2
NCBI Gene ID 406923
API
Download Associations
Predicted Functions View MIR133A2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR133A2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR133A2's ARCHS4 Predicted Functions.

Functional Associations

MIR133A2 has 260 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for MIR133A2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR133A2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR133A2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR133A2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR133A2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR133A2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR133A2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR133A2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GAD Gene-Disease Associations diseases associated with MIR133A2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR133A2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR133A2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR133A2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR133A2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR133A2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by MIR133A2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR133A2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR133A2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR133A2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR133A2 protein from the Wikipathways Pathways 2014 dataset.