MIR138-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 138-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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Its enforced expression downregulates key oncogenic mediators—such as cyclin D1, vimentin, PDK1, and YAP1—thereby inhibiting proliferation, invasion, metastasis, and even chemoresistance. These effects highlight its potential utility as a prognostic biomarker and therapeutic agent in multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in differentiation and tumor suppression, miR‑138‑1 regulates responses to cellular stress and treatment. By directly targeting histone H2AX, miR‑138‑1 can compromise homologous recombination repair and increase sensitivity to DNA‐damaging agents. It also modulates autophagic flux—via inhibition of SIRT1 and alteration of the FoxO1/Rab7 axis—and influences immune responses through exosome‐mediated transfer, thereby reprogramming macrophage polarization. In addition, by impacting inflammatory balance as observed in psoriasis and by modulating CD95‐triggered apoptosis, miR‑138‑1 contributes to the regulation of diverse stress‐responsive and cell survival pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neuronal contexts, miR‑138‑1 plays a critical dual role. It promotes herpes simplex virus 1 latency by repressing lytic gene expression through direct targeting of viral transcripts (e.g. ICP0) and host factors such as Oct‑1 and Foxc1. Concurrently, its dysregulation in the brain is linked to neurodegenerative changes, as elevated miR‑138‑1 enhances tau phosphorylation through the retinoic acid receptor alpha/GSK‑3β pathway, thereby implicating the microRNA in both viral and neurodegenerative pathologies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tilde Eskildsen, Hanna Taipaleenmäki, Jan Stenvang, et al. 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Synonyms MIR-138-1, MIRN138-1
NCBI Gene ID 406929
API
Download Associations
Predicted Functions View MIR138-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR138-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR138-1's ARCHS4 Predicted Functions.

Functional Associations

MIR138-1 has 730 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR138-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR138-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR138-1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR138-1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CTD Gene-Disease Associations diseases associated with MIR138-1 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR138-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR138-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR138-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR138-1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR138-1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR138-1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR138-1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR138-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR138-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR138-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR138-1 protein from the Wikipathways Pathways 2014 dataset.