MIR140 Gene

HGNC Family Non-coding RNAs
Name microRNA 140
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In various studies it has been shown to inhibit cell proliferation, invasion, metastasis and even chemoresistance in osteosarcoma, non‐small cell lung cancer, breast cancer, colorectal cancer, gastric cancer, and hepatocellular carcinoma. Mechanistically, MIR140 and its mature forms (both the –5p and –3p strands) exert these effects by directly targeting a range of oncogenic transcripts involved in key signaling pathways such as TGF‐β, MAPK/ERK, and Wnt (via targets including HDAC4, TGFBR1, FGF9, IGF1R, Smad2, VEGF‐A, YES1, ATP8A1, FEN1, BRD9, and Wnt1). In addition, dysregulation of MIR140 activity can occur through competitive binding by oncogenic long noncoding RNAs (for example, MALAT1, H19, HOXA11‐AS, PVT1, and circRNAs) that “sponge” MIR140, thereby de‐repressing its targets and fueling cancer stem cell properties and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond development and cancer, MIR140 is also implicated in other disease processes and in regulating stem cell fate. In vascular tissues, reduced MIR140‐5p levels contribute to pulmonary arterial hypertension by promoting smooth muscle cell proliferation and migration via dysregulation of BMP signaling. Moreover, in mesenchymal and adipocyte‐derived stem cells MIR140 helps modulate the balance between osteogenic and adipogenic differentiation. In joint tissues, MIR140 not only serves as a critical regulator of chondrocyte function and matrix integrity (for instance, via negative regulation of MMP‐13 and FUT1 in osteoarthritis) but is also emerging as a potential circulating biomarker for osteoporosis and rheumatoid arthritis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shigeru Miyaki, Tomoyuki Nakasa, Shuhei Otsuki, et al. 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Synonyms MIRNA140, MIR-140, MIRN140
NCBI Gene ID 406932
API
Download Associations
Predicted Functions View MIR140's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR140's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR140's ARCHS4 Predicted Functions.

Functional Associations

MIR140 has 629 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.

Click the + buttons to view associations for MIR140 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR140 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR140 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR140 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR140 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR140 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR140 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR140 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR140 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GAD Gene-Disease Associations diseases associated with MIR140 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR140 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR140 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR140 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR140 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR140 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR140 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR140 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR140 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR140 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by MIR140 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR140 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by MIR140 gene mutations from the MPO Gene-Phenotype Associations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR140 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR140 protein from the Wikipathways Pathways 2014 dataset.