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In colorectal and other cancers, competing endogenous RNAs (including circular RNAs and long noncoding RNAs like CCAT2, TUG1, and MALAT1) may sponge miR‐145, further subverting its suppressive functions. Moreover, miR‐145 is engaged in feed‐forward and feedback loops with master regulators such as p53, which not only enhances its expression but also reinforces differentiation and apoptosis while curbing cell cycle progression. This extensive tumor‐suppressive network has spurred interest in exploiting miR‐145 as a diagnostic biomarker and as a potential therapeutic agent for restoring normal cellular function in malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eduard Hergenreider, Susanne Heydt, Karine Tréguer, et al. 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