MIR1468 Gene

HGNC Family Non-coding RNAs
Name microRNA 1468
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn cervical cancer, exosome‐encapsulated miR-1468-5p is secreted by tumor cells and functions as a potent mediator of immunosuppression. It directly targets HMBOX1 within the SOCS1 promoter in lymphatic endothelial cells (LECs), thereby epigenetically activating the JAK2/STAT3 signaling cascade. This activation leads to upregulation of PD-L1 and promotes lymphangiogenesis, which together impair T cell–mediated anti-tumor immunity. High serum levels of exosomal miR-1468-5p also correlate with an immunosuppressive tumor microenvironment and poor prognosis in cervical cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma, miR-1468 is integrated into a circRNA molecular sponge regulatory network that appears to influence key oncogenic pathways. Here, dysregulation of miR-1468—alongside its interacting circular RNAs—has been associated with poor patient outcomes. The network suggests that miR-1468 may modulate the expression of critical genes such as EGFR, PTEN, and ITGA4, thereby impacting processes like apoptosis, cell adhesion, and signal transduction. These findings hint at a role for miR-1468 as both a prognostic biomarker and a potential therapeutic target in glioblastoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chenfei Zhou, Wenfei Wei, Jing Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2020.12.034"}], "href": "https://doi.org/10.1016/j.ymthe.2020.12.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33388421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33388421"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sara Tutunchi, Ahmad Bereimipour, Sayyed Mohammad Hossein Ghaderian "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-023-00735-w"}], "href": "https://doi.org/10.1007/s12033-023-00735-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37031335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37031335"}]}]}]}
Synonyms MIRN1468, HSA-MIR-1468, MIR-1468
NCBI Gene ID 100302115
API
Download Associations
Predicted Functions View MIR1468's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1468's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1468's ARCHS4 Predicted Functions.

Functional Associations

MIR1468 has 378 functional associations with biological entities spanning 4 categories (molecular profile, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1468 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1468 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1468 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1468 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1468 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1468 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR1468 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR1468 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1468 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1468 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1468 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1468 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.