{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-1470 is involved in cancer progression through multiple molecular pathways. In hepatocellular carcinoma, miR-1470 has been implicated as a contributor to tumor development, suggesting that its aberrant expression may underlie the malignant behavior of these cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, investigations in the context of lapatinib treatment have demonstrated that miR-1470 directly targets the 3′‐untranslated region of c-jun transcripts. This interaction results in downregulation of c-jun, leading to diminished cyclin D1 expression and the consequent upregulation of p27, a critical mediator of G₁ cell cycle arrest within the Her-2 signaling pathway. These findings not only underscore the versatile role of miR-1470 in modulating key oncogenic pathways but also indicate its potential as a therapeutic target in cancers where these mechanisms are deregulated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yijie Lu, Liu Yang, Ancheng Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1470 regulates cell proliferation and apoptosis by targeting ALX4 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.10.139"}], "href": "https://doi.org/10.1016/j.bbrc.2019.10.139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31791584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31791584"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weiwei Nie, Wei Song, Wenwen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1470 mediates lapatinib induced p27 upregulation by targeting c-jun."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24910"}], "href": "https://doi.org/10.1002/jcp.24910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25545366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25545366"}]}]}]}