MIR1471 Gene

HGNC Family Non-coding RNAs
Name microRNA 1471
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNon-coding RNAs are recognized for their critical roles in tumorigenesis, with emerging evidence suggesting that specific transcripts such as MIR1471 may be important regulators in cancer biology. Although the mechanistic details of many ncRNAs in malignancies—including breast cancer—remain to be fully elucidated, the broader context emphasizes the significance of these molecules in tumor regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn non‐small‐cell lung cancer (NSCLC), targeted studies have demonstrated that MIR1471 is markedly downregulated in tumor tissues. This downregulation correlates with advanced TNM staging and poor overall patient survival, highlighting its potential role as a tumor suppressor. Functional assays revealed that overexpression of MIR1471 results in reduced cell proliferative capacity and induces G1/S phase cell cycle arrest, suggesting that it plays a critical role in maintaining normal cellular proliferation dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nFurther investigation into its molecular mechanism uncovered FOXL1 mRNA as a direct target of MIR1471. By binding to FOXL1, MIR1471 effectively inhibits its translation, thereby exerting opposing effects on the proliferation and cell cycle progression of NSCLC cells. Collectively, these findings position MIR1471 as not only a functional regulator of tumor cell behavior but also a promising prognostic biomarker and potential therapeutic target in NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Liu, Tong Zhao, Xue Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LOC101930370/MiR-1471 Axis Modulates the Hedgehog Signaling Pathway in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000491980"}], "href": "https://doi.org/10.1159/000491980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30041193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30041193"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Donglei Shi, Kun Zhang, Guangquan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1471 protects the aggravation of non-small-cell lung carcinoma by targeting FOXL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biofactors (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/biof.1661"}], "href": "https://doi.org/10.1002/biof.1661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33045131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33045131"}]}]}]}
Synonyms MIRN1471, HSA-MIR-1471
NCBI Gene ID 100302126
API
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Predicted Functions View MIR1471's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1471's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1471's ARCHS4 Predicted Functions.

Functional Associations

MIR1471 has 246 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR1471 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1471 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1471 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1471 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1471 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1471 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1471 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1471 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR1471 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1471 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1471 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1471 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1471 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.