{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐147b has emerged as a multifunctional microRNA with diverse roles in cancer. In colorectal cancer, for example, miR‐147b is found to be suppressed via reciprocal interactions with oncogenic lncRNAs such as MAFG‑AS1, and differential expression patterns have been observed according to tumor localization, suggesting its involvement in tumor progression and patient prognosis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In ovarian carcinoma models, ectopic miR‐147b induces pro‑apoptotic signaling—with increased caspase activation and modulation of Bcl‑2 family proteins—highlighting its potential tumor‑suppressive action (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " By contrast, in other cancers its overexpression has been linked to aggressive phenotypes. Studies comparing miR‑147b with closely related homologs such as miR‑147a and miR‑210 have revealed that even subtle differences in the seed region can translate into distinct effects on cell proliferation and migration (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Furthermore, investigations in colorectal cancer have noted unresolved aspects of its function (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in non‑small cell lung cancer, miR‑147b promotes a reversible drug‑tolerant state to EGFR inhibition through modulation of metabolic and pseudohypoxic pathways (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In lung squamous cell carcinoma, its upregulation is associated with poor prognosis, and similar oncogenic contributions have been documented in prostate, pancreatic, and even cervical cancers—where it targets regulators such as IRX5—to enhance malignant behaviors (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor biology, miR‑147b is a key regulator of inflammatory processes. Notably, the transcript encoding Modulator of cytochrome C oxidase during Inflammation (MOCCI) also gives rise to miR‑147b; here the miRNA functions to target NDUFA4, thereby attenuating mitochondrial membrane potential and reactive oxygen species generation—a dual action that both dampens tissue‐damaging inflammation and bolsters antiviral immunity (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In astrocytes, overexpression of miR‑147b leads to reduced levels of pro‑inflammatory mediators such as IL‑6 and COX‑2, and promotes neuronal differentiation while modulating astrocyte proliferation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In stark contrast, in rheumatoid arthritis models, enhanced miR‑147b activity contributes to synovial inflammation by repressing targets like ZNF148 and upregulating cytokines and matrix metalloproteinases, an effect that appears to drive joint destruction; concurrently, circulating miR‑147b levels have been validated as promising prognostic markers in sepsis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the vascular context, miR‑147b also contributes to the maintenance of endothelial barrier function. 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