{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐150 is a versatile, small non‐coding RNA that plays essential roles in normal hematopoiesis and intercellular communication. In developmental models and immune cells, miR‐150 has been shown to directly target transcription factors such as c‐Myb—thereby modulating cell differentiation in zebrafish and human hematopoietic lineages—and to become strongly up‐regulated during T‐cell maturation where it suppresses Notch3, ultimately influencing proliferation and survival. Moreover, miR‐150 can be actively secreted in microvesicles from monocytes, acting in a paracrine manner to promote endothelial cell migration, while its aberrant expression in natural killer/T‐cell malignancies underscores its tumor–suppressive activities in certain lymphoid contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer settings, miR‐150 exhibits context‐dependent functions. In certain tumors, such as gastric cancer, its overexpression promotes tumorigenesis via direct targeting of tumor–suppressor genes (eg, EGR2), whereas in others—including pancreatic, colorectal, hepatocellular, esophageal, ovarian and some forms of leukemia and lung cancer—miR‐150 acts as a tumor suppressor by downregulating key oncogenes and mediators of epithelial–mesenchymal transition (eg, MUC4, ZEB1, VEGFA, MMP14, FOXO4). In these cancers its expression is often perturbed by competing endogenous RNAs such as lncRNAs (ZFAS1, CASC11) or circular RNAs (eg, cir‐ZNF609), which sequester miR‐150 and thereby abrogate its regulatory functions. These studies collectively indicate that restoring miR‐150 levels or interfering with its upstream inhibitory networks may represent novel therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles within cells, miR‐150 is emerging as an important circulating biomarker in several non–neoplastic conditions. Altered levels have been linked to sepsis and myocardial infarction and are associated with parameters such as left ventricular remodeling, pulmonary arterial hypertension, and even radiation–induced tissue injury. In fibrotic disorders such as lupus nephritis, miR‐150 contributes to pathological extracellular matrix deposition by targeting antifibrotic mediators (eg, SOCS1). Furthermore, its levels in serum or platelets correlate with disease severity in conditions ranging from heart failure to irritable bowel syndrome, underscoring its potential utility as a diagnostic and prognostic tool in diverse pathological states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Atsushi Suzuki, Chafik Ghayor, Jérome Guicheux, et al. 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