{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study investigating acute ischemic stroke, circulating serum levels of miR-151b were found to be significantly elevated in patients compared with healthy controls, and these increased levels were negatively correlated with circulating insulin-like growth factor-1 (IGF-1). This finding suggests that miR-151b, together with other miRNAs, may serve as a potential blood-based diagnostic biomarker for ischemic stroke, aiding in early detection and possibly reflecting alterations in growth factor signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn another study focused on ovarian cancer, a variant of miR-151 (miR-151-3p) was identified as part of a competing endogenous RNA network. Here, the circular RNA circ_0007841 was shown to function as a molecular sponge for miR-151-3p, thereby facilitating the upregulation of MEX3C expression. The resulting increase in MEX3C levels promoted malignant behaviors including enhanced proliferation, migration, and invasion of ovarian cancer cells, underscoring a potential tumor-suppressive role for miR-151-3p in this oncogenic axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiuli Cheng, Pengcheng Kan, Zhuolin Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploring the potential value of miR-148b-3p, miR-151b and miR-27b-3p as biomarkers in acute ischemic stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20181033"}], "href": "https://doi.org/10.1042/BSR20181033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30361294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30361294"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kejin Huang, Dan Liu, Changlei Su "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202911"}], "href": "https://doi.org/10.18632/aging.202911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33896797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33896797"}]}]}]}