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Through these actions, miR‐155 supports proper immune cell differentiation and function—ensuring efficient pathogen clearance while simultaneously acting as a negative feedback regulator to prevent excessive inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its immunoregulatory roles, miR‐155 functions as an oncomiR in several human cancers. It is frequently overexpressed in tumors such as breast cancer, pancreatic adenocarcinoma, colorectal cancer, diffuse large B‐cell lymphoma, and chronic lymphocytic leukemia. By targeting tumor suppressors and key signaling mediators—including SOCS1, VHL, SMAD5, and regulators of the cell cycle and DNA repair—miR‐155 promotes malignant transformation, tumor progression, angiogenesis, and even chemoresistance. 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In musculoskeletal tissues, altered miR‐155 levels have been linked to enhanced apoptosis via deregulation of FADD and caspase‑3 in intervertebral disc degeneration, while endothelial cell–derived exosomal miR‐155 contributes to bone homeostasis by inhibiting osteoclast differentiation, offering novel therapeutic avenues for disorders like osteoporosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Isabella Faraoni, Francesca Romana Antonetti, John Cardone, et al. 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