{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified miR‑1587 as a critical mediator in tumor progression. In glioblastoma, exosomes released by glioma‑associated human mesenchymal stem cells carry miR‑1587, which enhances the proliferation and clonogenic capacity of glioma stem‐like cells by downregulating the tumor‑suppressive nuclear receptor corepressor NCOR1. In breast cancer, M2‑polarized macrophages promote cell proliferation and migration by upregulating miR‑1587, which targets and suppresses interferon regulatory factor 7 (IRF7), thereby facilitating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of keloids, miR‑1587 is involved in regulating fibroblast behavior. Although miR‑1587 is downregulated in keloid tissues and human skin keloid fibroblasts, treatment with botulinum toxin A restores its expression, which in turn targets and suppresses ZEB2. This molecular modulation leads to inhibited fibroblast proliferation and migration, while promoting apoptosis and autophagy, suggesting a potential therapeutic pathway for keloid treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, miR‑1587 has been shown to adopt G‑quadruplex structures that facilitate its interaction with proteins such as CASK. This binding event is associated with the downstream transcriptional and translational downregulation of reelin and p21, indicating that miR‑1587 may play a broader role in modulating intracellular metabolic and transcriptional processes across multiple cancer cell types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Javier Figueroa, Lynette M Phillips, Tal Shahar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-2524"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-2524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28855213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28855213"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daoyuan Tu, Jin Dou, Mingkao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "M2 macrophages contribute to cell proliferation and migration of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11528"}], "href": "https://doi.org/10.1002/cbin.11528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33325089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33325089"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhanying Hou, Feixiang Fan, Po Liu "}, {"type": "b", "children": [{"type": "t", "text": "BTXA regulates the epithelial-mesenchymal transition and autophagy of keloid fibroblasts via modulating miR-1587/miR-2392 targeted ZEB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190679"}], "href": "https://doi.org/10.1042/BSR20190679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31652445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31652445"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lulu Zhang, Jiang Zhou, Ming Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploration of the Hsa-miR-1587-Protein Interaction and the Inhibition to CASK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms221910716"}], "href": "https://doi.org/10.3390/ijms221910716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34639058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34639058"}]}]}]}