{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR15A, a key component of the miR‐15/16 cluster, has emerged as an important tumor suppressor whose expression is frequently deleted or down‐regulated in several malignancies—including chronic lymphocytic leukemia (CLL), multiple myeloma, and various solid tumors. Multiple independent studies have demonstrated that loss of MIR15A expression contributes to tumorigenesis by impairing pro‐apoptotic responses and deregulating cell cycle progression. In CLL, for example, MIR15A (together with MIR16–1) normally functions to negatively regulate the anti‐apoptotic protein BCL2, thereby promoting apoptosis of malignant B cells. This tumor‐suppressive role has also been observed in other cancers, where reduced MIR15A levels are associated with increased cellular proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies reveal that MIR15A exerts its tumor‐suppressive effect by directly targeting critical oncogenic transcripts. Beyond repressing BCL2, MIR15A modulates the expression of several genes involved in cell‐cycle control—including cyclin D1 and MCL1—as well as pathways controlling apoptosis, proliferation, and even angiogenesis. Additional research has identified that MIR15A is embedded in complex regulatory networks involving transcription factors such as E2F1 and c-Myc, which govern its transcriptional regulation. These multifaceted interactions underscore the role of MIR15A not only in promoting programmed cell death but also in ensuring proper cell cycle exit."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, down-regulation of MIR15A has been closely linked to disease progression, chemoresistance, and metastasis. Its loss not only contributes to an impaired apoptotic response and deregulated cell proliferation but also affects the tumor microenvironment—impacting processes such as angiogenesis and drug sensitivity. As a consequence, experimental restoration of MIR15A levels has been shown to resensitize cancer cells to apoptosis and inhibit tumor growth and invasion in a variety of models, highlighting its potential as a therapeutic target. These findings suggest that strategies aimed at reconstituting MIR15A activity may provide novel avenues for the treatment of cancers characterized by its loss."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amelia Cimmino, George Adrian Calin, Muller Fabbri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-15 and miR-16 induce apoptosis by targeting BCL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0506654102"}], "href": "https://doi.org/10.1073/pnas.0506654102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16166262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16166262"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "George A Calin, Amelia Cimmino, Muller Fabbri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-15a and miR-16-1 cluster functions in human leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0800121105"}], "href": "https://doi.org/10.1073/pnas.0800121105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18362358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18362358"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lin Xia, Dexin Zhang, Rui Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.23501"}], "href": "https://doi.org/10.1002/ijc.23501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18449891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18449891"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huiwu Zhao, Anna Kalota, Shenghao Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-01-136218"}], "href": "https://doi.org/10.1182/blood-2008-01-136218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18818396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18818396"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Aldo M Roccaro, Antonio Sacco, Brian Thompson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-01-198408"}], "href": "https://doi.org/10.1182/blood-2009-01-198408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19401561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19401561"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "R I Aqeilan, G A Calin, C M Croce "}, {"type": "b", "children": [{"type": "t", "text": "miR-15a and miR-16-1 in cancer: discovery, function and future perspectives."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2009.69"}], "href": "https://doi.org/10.1038/cdd.2009.69"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19498445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19498445"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nora Bandi, Samuel Zbinden, Mathias Gugger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-4277"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-4277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19549910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19549910"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Katy Hanlon, Claudius E Rudin, Lorna W Harries "}, {"type": "b", "children": [{"type": "t", "text": "Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007169"}], "href": "https://doi.org/10.1371/journal.pone.0007169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19779621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19779621"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Resham Bhattacharya, Milena Nicoloso, Rochelle Arvizo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-2552"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-2552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19903841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19903841"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ulf Klein, Marie Lia, Marta Crespo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2009.11.019"}], "href": "https://doi.org/10.1016/j.ccr.2009.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20060366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20060366"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Goswin Y Meyer-Rochow, Nicole E Jackson, John V Conaglen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/ERC-10-0142"}], "href": "https://doi.org/10.1677/ERC-10-0142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20621999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20621999"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Vijay G Sankaran, Tobias F Menne, Danilo Šćepanović, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1018384108"}], "href": "https://doi.org/10.1073/pnas.1018384108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21205891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21205891"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Matan Ofir, Dalia Hacohen, Doron Ginsberg "}, {"type": "b", "children": [{"type": "t", "text": "MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-10-0344"}], "href": "https://doi.org/10.1158/1541-7786.MCR-10-0344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454377"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "M Musumeci, V Coppola, A Addario, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.140"}], "href": "https://doi.org/10.1038/onc.2011.140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21532615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21532615"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Nora Bandi, Erik Vassella "}, {"type": "b", "children": [{"type": "t", "text": "miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-10-55"}], "href": "https://doi.org/10.1186/1476-4598-10-55"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21575235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21575235"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Enzo R Porrello, Brett A Johnson, Arin B Aurora, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.111.248880"}], "href": "https://doi.org/10.1161/CIRCRESAHA.111.248880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21778430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21778430"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Deepa Sampath, Chaomei Liu, Karthik Vasan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-05-351510"}], "href": "https://doi.org/10.1182/blood-2011-05-351510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22096249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22096249"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shen-meng Gao, Chong-yun Xing, Chi-qi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-9966-30-110"}], "href": "https://doi.org/10.1186/1756-9966-30-110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22133358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22133358"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Cheng-Kui Cai, Guang-Yi Zhao, Li-Ying Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2012.1995"}], "href": "https://doi.org/10.3892/or.2012.1995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22922827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22922827"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Chun-Yan Sun, Xiao-Mei She, You Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgs333"}], "href": "https://doi.org/10.1093/carcin/bgs333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23104180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23104180"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Qifeng Luo, Xiaoyu Li, Jia Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2013.2034"}], "href": "https://doi.org/10.3892/ijo.2013.2034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23900351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23900351"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lei Shi, Rene Jackstadt, Helge Siemens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-2203"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-2203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24285725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24285725"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Y Pekarsky, C M Croce "}, {"type": "b", "children": [{"type": "t", "text": "Role of miR-15/16 in CLL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2014.87"}], "href": "https://doi.org/10.1038/cdd.2014.87"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24971479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24971479"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Anke J Tijsen, Ingeborg van der Made, Maarten M van den Hoogenhof, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The microRNA-15 family inhibits the TGFβ-pathway in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvu184"}], "href": "https://doi.org/10.1093/cvr/cvu184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25103110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25103110"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Wang Renjie, Liang Haiqian "}, {"type": "b", "children": [{"type": "t", "text": "MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.10.003"}], "href": "https://doi.org/10.1016/j.canlet.2014.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25305447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25305447"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Tian Yang, Asmitananda Thakur, Tianjun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3075-1"}], "href": "https://doi.org/10.1007/s13277-015-3075-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25874488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25874488"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Shailendra Kumar Dhar Dwivedi, Soumyajit Banerjee Mustafi, Lingegowda S Mangala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic evaluation of microRNA-15a and microRNA-16 in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7618"}], "href": "https://doi.org/10.18632/oncotarget.7618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26918603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26918603"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Naama Volk, Julius C Pape, Mareen Engel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.10.038"}], "href": "https://doi.org/10.1016/j.celrep.2016.10.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27829158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27829158"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Liangfeng Jiang, Zhiming Wu, Xingcheng Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOXA-AS2 Facilitates Tumorigenesis and Progression of Papillary Thyroid Cancer by Modulating the miR-15a-5p/HOXA3 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/hum.2018.109"}], "href": "https://doi.org/10.1089/hum.2018.109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30375256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30375256"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Lanyun Zhou, Wei Wang, Fenfen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-021-01352-4"}], "href": "https://doi.org/10.1186/s12943-021-01352-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33781255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33781255"}]}]}]}