{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR17, a key microRNA embedded in the polycistronic miR‐17–92 cluster, plays multifaceted roles in cancer biology. Aberrant over‐expression of this cluster has been documented in various malignancies—including B‐cell lymphomas, retinoblastoma, pancreatic cancer, clear cell renal carcinoma, and hepatocellular carcinoma—where it cooperates with oncogenic drivers such as c‐Myc and E2F. In these settings, MIR17 contributes to enhanced proliferation and survival by directly targeting tumor suppressors (for example, PTEN and pro‐apoptotic factors like Bim) and cell cycle inhibitors (such as CDKN1A/p21), while engaging in complex positive and negative feedback loops with regulators like cyclin D1. Intriguingly, in specific breast cancer contexts MIR17 may act in a tumor‐suppressive manner by down‐regulating AIB1 and thereby attenuating estrogen receptor signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic functions, MIR17 also modulates diverse aspects of cellular behavior including differentiation, migration, invasion, and stress responses. By targeting key regulators such as HBP1 and SMAD7, MIR17 can affect pathways including Wnt/β‐catenin signaling and fibronectin expression, thereby influencing epithelial–mesenchymal transitions and metastatic potential. Its expression is likewise dynamically regulated during aging and immune cell activation—for instance, altered MIR17 levels have been linked to T‐cell activation changes in multiple sclerosis and to shifts in mesenchymal stem cell lineage commitment that impact osteogenic differentiation. Moreover, in certain solid tumors and chemoresistant cellular models, MIR17 deregulation is associated with modifications in autophagy and endothelial adhesion, further underscoring its pivotal role in both malignant progression and tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIR17’s influence is not confined solely to cancer. It is increasingly recognized as a modulator in non‐neoplastic contexts and as a candidate biomarker. Studies have implicated MIR17 in neuronal cell cycle arrest during differentiation and in the regulation of stem cell populations. Altered MIR17 expression contributes to nonmalignant disorders such as autosomal dominant polycystic kidney disease and non‐traumatic osteonecrosis, while long noncoding RNAs—including the MIR17 host gene (MIR17HG) and HOTAIR—further refine MIR17’s activity through competitive endogenous RNA interactions. Moreover, circulating MIR17 levels have garnered attention as potential diagnostic markers, and viral mechanisms have been described that selectively down‐regulate MIR17 to modulate host cell responses. Collectively, these observations underscore the promise of therapeutically targeting MIR17 or its regulatory network in a broad spectrum of disease settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin He, J Michael Thomson, Michael T Hemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A microRNA polycistron as a potential human oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature03552"}], "href": "https://doi.org/10.1038/nature03552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15944707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15944707"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kathryn A O'Donnell, Erik A Wentzel, Karen I Zeller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Myc-regulated microRNAs modulate E2F1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature03677"}], "href": "https://doi.org/10.1038/nature03677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15944709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15944709"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Letizia Venturini, Karin Battmer, Mirco Castoldi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-09-045104"}], "href": "https://doi.org/10.1182/blood-2006-09-045104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17284533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17284533"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Changchun Xiao, Lakshmi Srinivasan, Dinis Pedro Calado, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni1575"}], "href": "https://doi.org/10.1038/ni1575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18327259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18327259"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zuoren Yu, Chenguang Wang, Min Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200801079"}], "href": "https://doi.org/10.1083/jcb.200801079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18695042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18695042"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nicole Cloonan, Mellissa K Brown, Anita L Steptoe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/gb-2008-9-8-r127"}], "href": "https://doi.org/10.1186/gb-2008-9-8-r127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18700987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18700987"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "M T Pickering, B M Stadler, T F Kowalik "}, {"type": "b", "children": [{"type": "t", "text": "miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.372"}], "href": "https://doi.org/10.1038/onc.2008.372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18836483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18836483"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Baltazar D Aguda, Yangjin Kim, Melissa G Piper-Hunter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0811166106"}], "href": "https://doi.org/10.1073/pnas.0811166106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19066217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19066217"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tsz-Fung F Chow, Marina Mankaruos, Andreas Scorilas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Urol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.juro.2009.09.086"}], "href": "https://doi.org/10.1016/j.juro.2009.09.086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20022054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20022054"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Fu Yang, Yixuan Yin, Fang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.23566"}], "href": "https://doi.org/10.1002/hep.23566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20209605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20209605"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jun Yu, Kenoki Ohuchida, Kazuhiro Mizumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.10.8.13083"}], "href": "https://doi.org/10.4161/cbt.10.8.13083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20703102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20703102"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sze Wan Shan, Ling Fang, Tatiana Shatseva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.122895"}], "href": "https://doi.org/10.1242/jcs.122895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23418359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23418359"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Anwar Hossain, Macus T Kuo, Grady F Saunders "}, {"type": "b", "children": [{"type": "t", "text": "Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00242-06"}], "href": "https://doi.org/10.1128/MCB.00242-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16940181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16940181"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ayumu Taguchi, Kiyoshi Yanagisawa, Masaharu Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-6460"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-6460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18632605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18632605"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Saara M Rissanen, Markku Kankaanpää, Alexander Meigal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Surface EMG and acceleration signals in Parkinson's disease: feature extraction and cluster analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Biol Eng Comput (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11517-008-0369-0"}], "href": "https://doi.org/10.1007/s11517-008-0369-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18633662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18633662"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Erin Connolly, Margherita Melegari, Pablo Landgraf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2008.080096"}], "href": "https://doi.org/10.2353/ajpath.2008.080096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18688024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18688024"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yajaira Suárez, Chen Wang, Thomas D Manes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0902369"}], "href": "https://doi.org/10.4049/jimmunol.0902369"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19949084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19949084"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Raija L P Lindberg, Francine Hoffmann, Matthias Mehling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200940032"}], "href": "https://doi.org/10.1002/eji.200940032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20148420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20148420"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hongling Li, Chunjing Bian, Lianming Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-010-0954-4"}], "href": "https://doi.org/10.1007/s10549-010-0954-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20505989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20505989"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Duaa Dakhlallah, Kara Batte, Yijie Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.201205-0888OC"}], "href": "https://doi.org/10.1164/rccm.201205-0888OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23306545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23306545"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Haoran Li, Burton B Yang "}, {"type": "b", "children": [{"type": "t", "text": "Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.810"}], "href": "https://doi.org/10.18632/oncotarget.810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23391506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23391506"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Hongling Li, Tangping Li, Shihua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.scr.2012.11.007"}], "href": "https://doi.org/10.1016/j.scr.2012.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23399447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23399447"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yael Nemlich, Eyal Greenberg, Rona Ortenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI62980"}], "href": "https://doi.org/10.1172/JCI62980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23728176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23728176"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Sanghyun Lee, Jaewon Song, Sungchul Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective degradation of host MicroRNAs by an intergenic HCMV noncoding RNA accelerates virus production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2013.05.007"}], "href": "https://doi.org/10.1016/j.chom.2013.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23768492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23768492"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Abhisek Chatterjee, Dhrubajyoti Chattopadhyay, Gopal Chakrabarti "}, {"type": "b", "children": [{"type": "t", "text": "miR-17-5p downregulation contributes to paclitaxel resistance of lung cancer cells through altering beclin1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0095716"}], "href": "https://doi.org/10.1371/journal.pone.0095716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24755562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24755562"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jie Jia, Xiaobo Feng, Weihua Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in non-traumatic osteonecrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emm.2014.43"}], "href": "https://doi.org/10.1038/emm.2014.43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25060766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25060766"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Swati Dhar, Avinash Kumar, Agnes M Rimando, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4877"}], "href": "https://doi.org/10.18632/oncotarget.4877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26318586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26318586"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Ranjeet Kumar, Sanjaya Kumar Sahu, Manish Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 17-5p regulates autophagy in Mycobacterium tuberculosis-infected macrophages by targeting Mcl-1 and STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cmi.12540"}], "href": "https://doi.org/10.1111/cmi.12540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26513648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26513648"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Lin Liu, Jian Yang, Xuchao Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.13741"}], "href": "https://doi.org/10.1111/febs.13741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27093644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27093644"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Biaofang Wei, Wei Wei, Baoxiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0169097"}], "href": "https://doi.org/10.1371/journal.pone.0169097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28207735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28207735"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Hui Zhou, Jun-Ming Guo, Yan-Ru Lou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-010-0617-2"}], "href": "https://doi.org/10.1007/s00109-010-0617-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20349219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20349219"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Mathew B Cox, Murray J Cairns, Kaushal S Gandhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012132"}], "href": "https://doi.org/10.1371/journal.pone.0012132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20711463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20711463"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Hans-Ingo Trompeter, Hassane Abbad, Katharina M Iwaniuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0016138"}], "href": "https://doi.org/10.1371/journal.pone.0016138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21283765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21283765"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Sachin Hajarnis, Ronak Lakhia, Matanel Yheskel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14395"}], "href": "https://doi.org/10.1038/ncomms14395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28205547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28205547"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Jie Xu, Qingtao Meng, Xiaobo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-18-3880"}], "href": "https://doi.org/10.1158/0008-5472.CAN-18-3880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31409641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31409641"}]}]}]}