{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn the context of endothelial dysfunction induced by chronic hyperglycemia, the long non‐coding RNA MIR181A2HG plays an essential regulatory role by acting as a molecular sponge. Under normal conditions, MIR181A2HG binds to specific microRNAs (miR‐6832‑5p, miR‐6842‑5p, and miR‑8056) that target the 3′UTR of AKT2 mRNA, thereby maintaining AKT2 expression and supporting typical human umbilical vein endothelial cell (HUVEC) proliferation, migration, and capillary‐like structure formation. However, persistent high glucose levels downregulate MIR181A2HG, resulting in elevated microRNA levels and subsequent suppression of AKT2. This dysregulation impairs HUVEC functions, alters glucose metabolism, and suggests that the MIR181A2HG/miRNA/AKT2 axis could be a promising therapeutic target for diabetic vascular disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Complementarily, emerging research into psoriasis pathogenesis has begun to explore the impact of MIR181A2HG on keratinocyte proliferation—a critical feature of the disease. Preliminary findings indicate that altered expression of MIR181A2HG may underlie the abnormal hyperproliferation of keratinocytes observed in psoriatic lesions, implicating this lncRNA in the chronic inflammatory processes that drive psoriasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shaohua Wang, Bin Zheng, Hongye Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2021.4868"}], "href": "https://doi.org/10.3892/ijmm.2021.4868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33537821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33537821"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingzhao Li, Mutian Niu, Xiaomei Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p/SOX6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.205902"}], "href": "https://doi.org/10.18632/aging.205902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38848163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38848163"}]}]}]}