{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐182 is increasingly recognized as a multifunctional regulator whose dysregulation contributes to diverse oncogenic processes. In breast, ovarian, and melanoma models, miR‐182 exerts oncogenic effects by targeting tumor suppressors and key DNA repair and apoptotic regulators. For example, in breast cancer miR‐182 represses FOXO1 and BRCA1 to impair cell cycle control and DNA repair, while in ovarian cancer and melanoma it downregulates factors such as PDCD4, MITF, and FOXO3 that normally constrain cell proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition, studies in glioblastoma have shown that miR‐182 targets anti‐apoptotic and growth‐promoting genes (such as Bcl2L12, c‐Met, and HIF2A), thereby modulating treatment response and tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its oncogenic role is further underscored in glioma where miR‐182 suppresses the negative regulator CYLD to sustain NF‑κB signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and in bladder cancer and hepatocellular carcinoma where elevated miR‐182 levels correlate with poor prognosis and early recurrence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its impact on cell survival and DNA repair, miR‐182 has been implicated in the control of metastasis, invasion, and therapeutic response. In hepatocellular carcinoma, for instance, miR‐182 targets metastasis suppressor genes such as MTSS1, while in high‐grade serous ovarian carcinoma its overexpression facilitates early tumor transformation by deregulating BRCA1, MTSS1, and HMGA2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " As a key component of the miR‐183/96/182 polycistronic cluster frequently upregulated in breast cancers, miR‐182 contributes to the metastatic cascade by promoting cell motility and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", a finding supported by glioma studies correlating high miR‐182 expression with aggressive disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In prostate cancer, miR‐182 enhances proliferation and invasiveness by directly targeting FOXF2, RECK, and MTSS1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", while its aberrant levels in periodontitis are linked to impaired osteogenic differentiation through a regulatory network involving FoxO1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Intriguingly, miR‐182 also modulates non‐oncologic processes such as circadian rhythm regulation in major depression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and supports tumor cell survival and proliferation in colon cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMiR‐182 additionally interfaces with critical metabolic and signaling pathways across cancer types. In prostate cancer, it regulates cellular zinc homeostasis by suppressing the zinc transporter hZIP1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", and in lung cancer, studies indicate that as part of the miR‐183/96/182 cluster, miR‐182 targets Foxf2 to modulate epithelial–mesenchymal transition and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " In bladder cancer, miR‐182 overexpression impairs tumor suppressive mechanisms by targeting Smad4 and RECK, thereby activating the Wnt/β‑catenin pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", while in ovarian malignancies its suppression of PDCD4 enhances proliferation and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Conversely, in gastric adenocarcinoma, miR‐182 appears to act as a tumor suppressor by targeting CREB1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ", and its pro‐metastatic activity in breast cancer has been linked to repression of MIM leading to enhanced RhoA signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " In uveal melanoma, miR‐182 overexpression induces cell cycle arrest and apoptosis by targeting MITF, BCL2, and cyclin D2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ", whereas in other metastatic cancer models, TGF‑β–mediated upregulation of miR‐182 disrupts SMAD7‐mediated feedback to potentiate invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": " Regulation of miR‐182 itself is complex, involving transcriptional and post‐transcriptional control by factors such as Sp1 and p53 as well as interactions with long noncoding RNAs like those described in studies of general oncogenic regulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "and in cervical"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": ", renal"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": ", and lung cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": " MiR‐182 also shows promise as a circulating biomarker in hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "and is modulated by lncRNA UCA1 in glioma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": " Moreover, upregulation of miR‐182 contributes to chemoresistance in HCC by targeting TP53INP1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "30"}]}, {"type": "t", "text": ", and in breast cancer, DDX5‐dependent regulation of miR‐182 influences actin cytoskeletal dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": " In colorectal cancer, miR‐182 (in concert with miR‐135b) targets ST6GALNAC2 to activate the PI3K/AKT pathway and promote drug resistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "32"}]}, {"type": "t", "text": ", while in lung cancer Sp1‐mediated induction of miR‐182 decreases FOXO3 expression to enhance proliferative and anti‐metastatic signals in early stages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "33"}]}, {"type": "t", "text": " Finally, miR‐182 has been included in broader lung cancer miRNA screening efforts, emphasizing its potential diagnostic value."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Irene K Guttilla, Bruce A White "}, {"type": "b", "children": [{"type": "t", "text": "Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.031427"}], "href": "https://doi.org/10.1074/jbc.M109.031427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19574223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19574223"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miguel F Segura, Douglas Hanniford, Silvia Menendez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0808263106"}], "href": "https://doi.org/10.1073/pnas.0808263106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19188590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19188590"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Patryk Moskwa, Francesca M Buffa, Yunfeng Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.12.005"}], "href": "https://doi.org/10.1016/j.molcel.2010.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21195000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21195000"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fotini M Kouri, Lisa A Hurley, Weston L Daniel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.257394.114"}], "href": "https://doi.org/10.1101/gad.257394.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25838542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25838542"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Libing Song, Liping Liu, Zhiqiang Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI62339"}], "href": "https://doi.org/10.1172/JCI62339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23006329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23006329"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Man-Qing Cao, A-Bin You, Xiao-Dong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-018-0555-y"}], "href": "https://doi.org/10.1186/s13045-018-0555-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29361949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29361949"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Géraldine Pignot, Geraldine Cizeron-Clairac, Sophie Vacher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA expression profile in a large series of bladder tumors: identification of a 3-miRNA signature associated with aggressiveness of muscle-invasive bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.27949"}], "href": "https://doi.org/10.1002/ijc.27949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23169479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23169479"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jian Wang, Jingwu Li, Junling Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-12-227"}], "href": "https://doi.org/10.1186/1471-2407-12-227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22681717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22681717"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhaojian Liu, Jinsong Liu, Miguel F Segura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4000"}], "href": "https://doi.org/10.1002/path.4000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22322863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22322863"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Pei Li, Cheng Sheng, Lingling Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13058-014-0473-z"}], "href": "https://doi.org/10.1186/s13058-014-0473-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25394902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25394902"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lili Jiang, Pu Mao, Libing Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-182 as a prognostic marker for glioma progression and patient survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2010.090812"}], "href": "https://doi.org/10.2353/ajpath.2010.090812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20472885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20472885"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hiroshi Hirata, Koji Ueno, Varahram Shahryari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0055502"}], "href": "https://doi.org/10.1371/journal.pone.0055502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23383207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23383207"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "L Wang, F Wu, Y Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2016.125"}], "href": "https://doi.org/10.1038/cddis.2016.125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27512949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27512949"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ester Saus, Virginia Soria, Geòrgia Escaramís, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq316"}], "href": "https://doi.org/10.1093/hmg/ddq316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20656788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20656788"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lina Cekaite, Juha K Rantala, Jarle Bruun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.121094"}], "href": "https://doi.org/10.1593/neo.121094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23019418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23019418"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Brittany L Mihelich, Ekaterina A Khramtsova, Nicole Arva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.262915"}], "href": "https://doi.org/10.1074/jbc.M111.262915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22045813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22045813"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "S T Kundu, L A Byers, D H Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.71"}], "href": "https://doi.org/10.1038/onc.2015.71"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25798833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25798833"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Hiroshi Hirata, Koji Ueno, Varahram Shahryari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0051056"}], "href": "https://doi.org/10.1371/journal.pone.0051056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23226455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23226455"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yu-Quan Wang, Ren-De Guo, Rui-Meng Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.24488"}], "href": "https://doi.org/10.1002/jcb.24488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23296900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23296900"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wei-Qing Kong, Ru Bai, Tao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2012.08519.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2012.08519.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22325466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22325466"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "R Lei, J Tang, X Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.65"}], "href": "https://doi.org/10.1038/onc.2013.65"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23474751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23474751"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Dongsheng Yan, Xiang Da Dong, Xiaoyan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040967"}], "href": "https://doi.org/10.1371/journal.pone.0040967"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22848417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22848417"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jingyi Yu, Rong Lei, Xueqian Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms13884"}], "href": "https://doi.org/10.1038/ncomms13884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27996004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27996004"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Chi-Hsiang Chiang, Ming-Feng Hou, Wen-Chun Hung "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of miR-182 by β-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2013.01.009"}], "href": "https://doi.org/10.1016/j.bbagen.2013.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23333633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23333633"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Tao Tang, Hoi Kin Wong, Wenyi Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-182 plays an onco-miRNA role in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2012.12.043"}], "href": "https://doi.org/10.1016/j.ygyno.2012.12.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23313739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23313739"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Xin Xu, Jian Wu, Shiqi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-109"}], "href": "https://doi.org/10.1186/1476-4598-13-109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24886554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24886554"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yihua Sun, Rong Fang, Chenguang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.04.127"}], "href": "https://doi.org/10.1016/j.bbrc.2010.04.127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20420807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20420807"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Weijie Zhang, Pengxu Qian, Xiao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.653261"}], "href": "https://doi.org/10.1074/jbc.M115.653261"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25873390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25873390"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Zongze He, Yujue Wang, Guangfu Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2017.01.013"}], "href": "https://doi.org/10.1016/j.abb.2017.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28137422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28137422"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jun Qin, Meng Luo, Haixin Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated miR-182 increases drug resistance in cisplatin-treated HCC cell by regulating TP53INP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2013.12.043"}], "href": "https://doi.org/10.1016/j.gene.2013.12.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24447717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24447717"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Daojing Wang, Jing Huang, Zhi Hu "}, {"type": "b", "children": [{"type": "t", "text": "RNA helicase DDX5 regulates microRNA expression and contributes to cytoskeletal reorganization in basal breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M111.011932"}], "href": "https://doi.org/10.1074/mcp.M111.011932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22086602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22086602"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Bing Liu, Yanfeng Liu, Lifen Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22710"}], "href": "https://doi.org/10.1002/mc.22710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28767179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28767179"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Wen-Bin Yang, Ping-Hsin Chen, Tsung Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp1-mediated microRNA-182 expression regulates lung cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1608"}], "href": "https://doi.org/10.18632/oncotarget.1608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24519909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24519909"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Wilson Roa, Bryan Brunet, Linghong Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a new microRNA expression profile as a potential cancer screening tool."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Invest Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.25011/cim.v33i2.12351"}], "href": "https://doi.org/10.25011/cim.v33i2.12351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20370992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20370992"}]}]}]}