{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated MIR1825 as a versatile regulator in both neurodegenerative and oncological contexts. In malignant glioma, for example, reduced serum levels of miR‐1825 correlate with advanced tumor grade, increased cell proliferation and invasion, and poorer overall survival. Functional assays indicate that miR‐1825 exerts tumor‐suppressive effects—at least in part by directly targeting key regulators such as KLF2—thus making it a promising candidate biomarker for tumor grading and prognosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "<br><br>\nIn the realm of neurodegeneration, diminished miR‐1825 expression in both central and peripheral tissues has been linked to amyotrophic lateral sclerosis (ALS). Here, loss of miR‐1825 leads to a translational upregulation of tubulin-folding cofactor B (TBCB), which in turn accelerates the depolymerization and degradation of TUBA4A—a known ALS-associated gene—culminating in motor axon defects. This discovery highlights a novel miR‐1825/TBCB/TUBA4A pathogenic cascade common to both familial and sporadic forms of ALS"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "<br><br>\nIn glioblastoma, although the precise regulatory mechanisms remain to be fully defined, emerging evidence reinforces the notion that miR‐1825 deregulation is an important element in the pathogenesis of aggressive brain tumors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "<br><br>\nBeyond primary brain tumors, MIR1825 also plays significant roles in other cancer types. In breast cancer, elevated serum miR‐1825 levels are found in pre‐operative patients compared to healthy controls, with higher levels associated with advanced stage, poor differentiation, and larger tumor size. Notably, the modulation of its serum concentration following surgery and chemotherapy suggests that miR‐1825 could serve as a dynamic biomarker for monitoring therapeutic efficacy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "<br><br>\nIn hepatic disease, increased expression of miR‐182‐5p—a close family member—with subsequent downregulation of tumor suppressors such as Cyld and Foxo1 has been observed during the progression from non‐alcoholic fatty liver disease to hepatocellular carcinoma. These findings, supported by both murine models and human datasets, underscore the diagnostic potential of miR‐182‐5p in differentiating normal from tumorous liver tissue"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "<br><br>\nMoreover, in oral squamous cell carcinoma, miR‐1825 is enriched in tumor-derived exosomes, where it appears to modulate angiogenesis under hypoxic conditions—a process that may facilitate tumor progression and metastasis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "<br><br>\nFinally, epigenetic regulation of the miR‐182 gene, such as promoter hypermethylation, has been documented in acute myeloid leukemia, leading to reduced miR‐182 expression in these malignant cells and suggesting another layer of control that might be relevant to MIR1825 function in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenli Xing, Chun Zeng "}, {"type": "b", "children": [{"type": "t", "text": "A novel serum microRNA-based identification and classification biomarker of human glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317705339"}], "href": "https://doi.org/10.1177/1010428317705339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28475008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28475008"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anika M Helferich, Sarah J Brockmann, Jörg Reinders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-018-2873-1"}], "href": "https://doi.org/10.1007/s00018-018-2873-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30030593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30030593"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fengqin Lu, Chunhong Li, Yuping Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-020-01927-3"}], "href": "https://doi.org/10.1186/s12957-020-01927-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32605563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32605563"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Y Y He, B Xiao, J H Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Study on the expression of microRNA-1825 in serum of pre-operative and post-operative patients with breast cancer]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yu Fang Yi Xue Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112150-20200921-01224"}], "href": "https://doi.org/10.3760/cma.j.cn112150-20200921-01224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34034413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34034413"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chiara Compagnoni, Roberta Capelli, Veronica Zelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-182-5p Is Upregulated in Hepatic Tissues from a Diet-Induced NAFLD/NASH/HCC C57BL/6J Mouse Model and Modulates Cyld and Foxo1 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24119239"}], "href": "https://doi.org/10.3390/ijms24119239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37298191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37298191"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ozel Capik, Rasim Gumus, Omer Faruk Karatas "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced tumor exosomes promote angiogenesis through miR-1825/TSC2/mTOR axis in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Head Neck (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hed.27460"}], "href": "https://doi.org/10.1002/hed.27460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37449548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37449548"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Danyang Li, Yigang Yuan, Chen Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-024-01658-2"}], "href": "https://doi.org/10.1186/s13148-024-01658-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38528641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38528641"}]}]}]}