MIR1827 Gene

HGNC Family Non-coding RNAs
Name microRNA 1827
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In small‐cell lung cancer, a single‐nucleotide polymorphism in the 3′‐UTR of the MYCL1 gene has been shown to disrupt binding by miR-1827, thereby increasing disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, miR-1827 targets MDM2 to enhance p53-mediated stress responses and tumor suppression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and in lung adenocarcinoma, its downregulation correlates with aggressive tumor behavior through impaired targeting of oncogenes such as MYC and FAM83F."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, delivery of miR-1827 via mesenchymal stem cell–derived exosomes has been reported to inhibit colorectal cancer progression by suppressing SUCNR1, thereby reducing metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non–small cell lung cancer, miR-1827 overexpression reduces anoikis resistance by directly targeting caveolin-1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in invasive ductal carcinoma of the breast, miR-1827 is an integral component of a ceRNA network involving LINC00092 and SFRP1, wherein its altered expression is associated with increased cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncogenesis, miR-1827 plays a role in differentiation and neural function. In maxillary sinus membrane stem cells, miR-1827 is upregulated during osteogenic differentiation but functions as a negative feedback regulator by targeting IGF1, ultimately inhibiting bone formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Its dysregulation has also been implicated in schizophrenia, where altered circulating levels of miR-1827 contribute to its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence further suggests that miR-1827 is involved in metabolic disease contexts. 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"}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7088"}], "href": "https://doi.org/10.18632/oncotarget.7088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26840028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26840028"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gongchun Fan, Peng Xu, Peng Tu "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29402"}], "href": "https://doi.org/10.1002/jcb.29402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31595558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31595558"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jierong Chen, Ziyue Li, Caifeng Yue, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-021-01945-0"}], "href": "https://doi.org/10.1007/s12031-021-01945-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34811713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34811713"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Min Li, Ai Zeng, Xinle Tang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR-1827."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.13456"}], "href": "https://doi.org/10.1111/1440-1681.13456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33644928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33644928"}]}]}]}
Synonyms HSA-MIR-1827, MIRN1827
NCBI Gene ID 100302217
API
Download Associations
Predicted Functions View MIR1827's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1827's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1827's ARCHS4 Predicted Functions.

Functional Associations

MIR1827 has 275 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR1827 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1827 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1827 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1827 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1827 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1827 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1827 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1827 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1827 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1827 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1827 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR1827 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1827 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.