{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the oncogenic role of miR‑1910‑3p in cancer progression. In breast cancer, exosomes carrying miR‑1910‑3p are secreted by tumor cells and subsequently transferred to both transformed and non‑transformed mammary epithelial cells. This miR promotes cellular proliferation and migration, suppresses apoptosis, and induces autophagy. Mechanistically, miR‑1910‑3p downregulates myotubularin‑related protein 3, thereby activating the NF‑κB and Wnt/β‑catenin signaling pathways, which facilitate tumor growth and metastasis. Furthermore, serum exosomal miR‑1910‑3p has shown promise as an effective diagnostic marker, especially when used in conjunction with the traditional tumor marker CA153."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDis primis, in the context of colorectal carcinoma (CRC), deregulation of miR‑1910‑3p is implicated in a novel regulatory axis involving the long noncoding RNA LINC00174 and the transcriptional coactivator TAZ. Upregulation of LINC00174 in CRC tissues drives aberrant activation of the LINC00174/miR‑1910‑3p/TAZ pathway, contributing to enhanced tumor cell proliferation and progression. This finding underscores the multifaceted oncogenic functions of miR‑1910‑3p in modulating key signaling cascades in diverse tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nFusce etiam, beyond its roles in neoplastic processes, miR‑1910‑3p has been evaluated in inflammatory conditions such as psoriasis. In this context, miR‑1910‑3p is among several microRNAs studied for its potential to target pivotal immune regulators, including FOXP3 and IL‑17A mRNAs. By modulating the expression of these molecules, miR‑1910‑3p may influence immune activation and contribute to the pathogenesis of psoriasis, thereby underscoring its diverse biological and clinical relevance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bo Wang, Jia-Hui Mao, Bing-Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2020.05.038"}], "href": "https://doi.org/10.1016/j.canlet.2020.05.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32531321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32531321"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying Shen, Xiao Gao, Wanyan Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.05.001"}], "href": "https://doi.org/10.1016/j.gene.2018.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29729381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29729381"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Melek Karabacak, İjlal Erturan, Kuyaş Hekimler Öztürk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Is microRNA 1910-3p (miR-1910-3p) a really distinctive marker for psoriasis?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Turk J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3906/sag-2009-156"}], "href": "https://doi.org/10.3906/sag-2009-156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33356031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33356031"}]}]}]}