{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies in hepatocellular carcinoma (HCC) have revealed a tumor‐suppressive role for miR‐1914. In HCC specimens and cell lines, reduced miR‐1914 expression correlates with increased tumor size and a higher histological grade. Functional analyses demonstrated that miR‐1914 overexpression inhibits tumor proliferation and colony formation by inducing cell cycle arrest and apoptosis, primarily by directly targeting GPR39 and thereby repressing the PI3K/AKT/mTOR pathway. In addition, modulation of miR‐1914 by lncRNA DUXAP10 further influences these cellular events. Complementary findings also indicate that in HepG2 cells, functional inhibition of miR‐1914‐5p alters lipid metabolism by increasing energy expenditure, reducing cell doubling time, and diminishing migration, which suggests a potential role in controlling metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer (CRC), miR‐1914 appears to function in an oncogenic manner. Analyses of CRC tissues and cell lines have shown that miR‐1914, alongside miR‐1647, is upregulated; their suppression using small interfering RNAs leads to reduced CRC cell proliferation and migration. Mechanistically, these miRNAs promote oncogenic activity by directly targeting and downregulating nuclear factor I/X (NFIX), thereby facilitating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer, miR‐1914‐5p also plays an important role in vascular inflammation associated with atherosclerosis. In inflammatory conditions, such as those triggered by interleukin‐1β, miR‐1914‐5p expression is reduced in monocytes, which in turn leads to the upregulation of adhesion molecules like Mac‐1 and chemotactic factors such as MCP‐1. These changes enhance monocyte adhesion to the endothelium and promote transmigration, key steps in atherogenesis. Conversely, overexpression of miR‐1914‐5p suppresses these inflammatory responses and may serve as a novel diagnostic marker and therapeutic target for atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liankang Sun, Liang Wang, Tianxiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1914, which is regulated by lncRNA DUXAP10, inhibits cell proliferation by targeting the GPR39-mediated PI3K/AKT/mTOR pathway in HCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14705"}], "href": "https://doi.org/10.1111/jcmm.14705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31576658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31576658"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marina Bonfogo da Silveira, Camila Cristiane Pansa, Osmar Malaspina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The functional activity of the miR-1914-5p in lipid metabolism of the hepatocarcinoma cell line HepG2: a potential molecular tool for controlling hepatic cellular migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-021-06364-3"}], "href": "https://doi.org/10.1007/s11033-021-06364-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33907947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33907947"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shaoqing Liu, Dingding Qu, Weiping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑647 and miR‑1914 promote cancer progression equivalently by downregulating nuclear factor IX in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7675"}], "href": "https://doi.org/10.3892/mmr.2017.7675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28990086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28990086"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kohki Toriuchi, Toshie Kihara, Hiromasa Aoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Monocyte-Derived miRNA-1914-5p Attenuates IL-1β-Induced Monocyte Adhesion and Transmigration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24032829"}], "href": "https://doi.org/10.3390/ijms24032829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36769149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36769149"}]}]}]}