{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐1915 plays multifaceted roles in cancer by modulating apoptotic signals and drug responsiveness. In colorectal carcinoma, reduced miR‐1915 expression is associated with multidrug resistance, and its restoration suppresses the anti‐apoptotic protein Bcl‐2 through direct targeting of its 3′‐UTR, thereby sensitizing cells to chemotherapeutics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In parallel, in gastric cancer, lowered miR‐1915‐3p levels correlate with elevated Bcl‐2 expression and enhanced cell survival, suggesting a tumor‐suppressive facet of miR‐1915 in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in other tumor settings miR‐1915‐3p appears to exert tumor‐promoting functions. In breast cancer, elevated serum levels of miR‐1915‐3p are linked to more aggressive phenotypes, as it enhances cell proliferation and migration—partly through repression of the target gene DUSP3 and activation of the ERK1/2 pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In non‐small‐cell lung cancer, overexpression of miR‐1915‐3p protects cells from apoptosis by directly downregulating DRG2 and PBX2, thereby contributing to chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor biology, miR‐1915 is involved in the regulation of normal differentiation processes. In the hematopoietic compartment, platelet‐derived microparticles deliver miR‐1915‐3p to hematopoietic stem/progenitor cells, where it suppresses a member of the Rho GTPase family (RhoB) to promote megakaryocytic differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Similarly, in adult renal progenitor cells, low baseline miR‐1915 levels help maintain stemness markers such as CD133 and PAX2, while upregulation of miR‐1915 favors differentiation into epithelial‐ and adipocyte‐like phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Furthermore, analyses in embryonal stem cells have identified miR‐1915 sequences that appear to participate in a feedback mechanism regulating Notch‐1 translation, thereby linking miRNA‐mediated control to stemness and epithelial–mesenchymal transition processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ke Xu, Xin Liang, Daling Cui, et al. 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