MIR193B Gene

HGNC Family Non-coding RNAs
Name microRNA 193b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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Notably, in glioma an opposite effect has been observed, where miR‐193b—by targeting Smad3—may promote tumor progression, emphasizing a context‐dependent function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in oncogenesis, miR‐193b also modulates non‐malignant physiological processes. In normal tissues, it exerts key functions in cartilage formation and homeostasis by regulating chondrocyte differentiation and senescence. Specifically, miR‐193b targets elements of the transforming growth factor‐β pathway (including TGFB2 and TGFBR3) and modulates histone deacetylases such as HDAC3 and HDAC7—actions that are important for maintaining extracellular matrix integrity and controlling inflammatory mediators like matrix metalloproteinases and inducible nitric oxide synthase in osteoarthritis. Moreover, by curbing trophoblast migration via TGF‐β2 and being detectable in circulating exosomes, miR‐193b holds promise as a non‐invasive biomarker, for example in preeclampsia and Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S-K Leivonen, R Mäkelä, P Ostling, et al. 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Synonyms MIRN193B, MIR-193B
NCBI Gene ID 574455
API
Download Associations
Predicted Functions View MIR193B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR193B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR193B's ARCHS4 Predicted Functions.

Functional Associations

MIR193B has 1,035 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for MIR193B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR193B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR193B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR193B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CTD Gene-Disease Associations diseases associated with MIR193B gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR193B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR193B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR193B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR193B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR193B from the GeneSigDB Published Gene Signatures dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR193B gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR193B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR193B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by MIR193B gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR193B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by MIR193B gene mutations from the MPO Gene-Phenotype Associations dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR193B gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR193B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.