{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe MIR193BHG locus encodes a long intergenic noncoding RNA, lincNORS, which is generated via alternative splicing and is entirely distinct from the previously characterized miR-193b-365a tandem. lincNORS is induced under low oxygen conditions and is responsive to estrogen signaling, enabling it to fine‐tune cellular sterol and steroid biosynthesis by repressing several key components of these pathways. Its activity is dependent on the RNA‐binding protein RALY, a factor implicated in cholesterol homeostasis, and the genomic vicinity of the MIR193BHG locus harbors variants associated with sterol/steroid-related phenotypes, including the timing of sexual maturation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its metabolic regulatory functions, altered expression of the MIR193BHG-encoded lncRNA has been observed in preeclampsia, a significant complication of late pregnancy. This dysregulation underscores a potential clinical significance for MIR193BHG in pregnancy-related disorders, suggesting that it may serve as a biomarker or regulator in the pathophysiology of preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xue Wu, Cristina M Niculite, Mihai Bogdan Preda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-18411-x"}], "href": "https://doi.org/10.1038/s41467-020-18411-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32958772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32958772"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Na Dong, Duanfei Li, Huilan Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of lncRNA MIR193BHG in serum of preeclampsia patients and its clinical significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gynecol Obstet Hum Reprod (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jogoh.2022.102357"}], "href": "https://doi.org/10.1016/j.jogoh.2022.102357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35301154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35301154"}]}]}]}