{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR196A1 is a multifunctional microRNA with a pivotal role in tumorigenesis and cancer progression. Numerous studies have demonstrated that aberrant over‐ or under‐expression of MIR196A1 in diverse malignancies—including esophageal, colorectal, melanoma, pituitary, cervical, oral, head and neck, ovarian, glioma, pancreatic, and hepatocellular carcinomas—modulates key cellular processes such as proliferation, migration, invasion, epithelial–mesenchymal transition, apoptosis, chemoresistance, and radioresistance. Mechanistically, MIR196A1 exerts its effects by directly suppressing targets such as Annexin A1, HOX family transcription factors (e.g. HOXC8 and HOX‐B7), netrin 4, p27^Kip1, and SOCS2, thereby influencing major signaling pathways like JAK/STAT and PI3K/Akt. In addition, single nucleotide polymorphisms in its precursor sequence have been linked to altered cancer risk and patient prognosis, underscoring its potential as a circulating biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its oncogenic functions, MIR196A1 plays critical roles in cellular differentiation, tissue development, and homeostasis. For instance, in human adipose tissue–derived mesenchymal stem cells, MIR196A1 regulates the balance between proliferation and osteogenic differentiation by targeting HOXC8, while in white adipose tissue it is induced by cold and β-adrenergic stimuli to promote the formation of metabolically active brown adipocyte–like cells via suppression of white-fat gene expression. MIR196A1 also exerts antiviral and cytoprotective effects in hepatitis C virus infection by downregulating Bach1 and upregulating the antioxidant enzyme HMOX1. Moreover, its abundant expression in the kidney—particularly in glomeruli and tubular epithelium—modulates the TGF-β/Smad signaling cascade to mitigate renal fibrosis, and it supports neuronal morphology and intracellular transport, thereby contributing to neuroprotection in Huntington’s disease models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence underscores the complexity of MIR196A1’s regulatory network through its interactions with long non-coding RNAs. Such cross‐talk—exemplified by its reciprocal regulation with lncRNAs like GAS5 and NEAT1—not only further refines critical oncogenic and differentiation pathways but also opens new avenues for its application as a prognostic marker and therapeutic target in both cancer and degenerative diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R Luthra, R R Singh, M G Luthra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.256"}], "href": "https://doi.org/10.1038/onc.2008.256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18663355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18663355"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Carl Christoph Schimanski, Kirsten Frerichs, Fareed Rahman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.15.2089"}], "href": "https://doi.org/10.3748/wjg.15.2089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19418581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19418581"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Simone Braig, Daniel W Mueller, Tanja Rothhammer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-010-0394-7"}], "href": "https://doi.org/10.1007/s00018-010-0394-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20480203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20480203"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanlei Guan, Masahiro Mizoguchi, Koji Yoshimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-10-0207"}], "href": "https://doi.org/10.1158/1078-0432.CCR-10-0207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20601442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20601442"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiangyu Kong, Yiqi Du, Guokun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of differentially expressed microRNAs in serum of pancreatic ductal adenocarcinoma patients: miR-196a could be a potential marker for poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-010-1285-3"}], "href": "https://doi.org/10.1007/s10620-010-1285-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20614181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20614181"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kai Wang, Hong Guo, Huamei Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/1354750X.2010.505299"}], "href": "https://doi.org/10.3109/1354750X.2010.505299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20722507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20722507"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Daniel W Mueller, Anja-Katrin Bosserhoff "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25768"}], "href": "https://doi.org/10.1002/ijc.25768"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21077158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21077158"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "D Palmieri, D D'Angelo, T Valentino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.557"}], "href": "https://doi.org/10.1038/onc.2011.557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22139073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22139073"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mi Jeong Hong, Yi Young Choi, Ji-Ae Jang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between genetic variants in pre-microRNAs and survival of early-stage NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thorac Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/JTO.0b013e318288dc0a"}], "href": "https://doi.org/10.1097/JTO.0b013e318288dc0a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23470291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23470291"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jie Zhang, Fangxia Zheng, Gang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.09.142"}], "href": "https://doi.org/10.1016/j.bbrc.2013.09.142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24120501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24120501"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yu-Xia Hao, Jun-Ping Wang, Long-Feng Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Associations between three common MicroRNA polymorphisms and hepatocellular carcinoma risk in Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2013.14.11.6601"}], "href": "https://doi.org/10.7314/apjcp.2013.14.11.6601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24377574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24377574"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wei Du, Xue-Lei Ma, Chong Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations of single nucleotide polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with colorectal cancer susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.2.1047"}], "href": "https://doi.org/10.7314/apjcp.2014.15.2.1047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24568449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24568449"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Vanessa Villegas-Ruiz, Sergio Juárez-Méndez, Oscar A Pérez-González, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterogeneity of microRNAs expression in cervical cancer cells: over-expression of miR-196a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24817935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24817935"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Soo Jung Lee, Jong Won Seo, Yee Soo Chae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphism of miR-196a as a prognostic biomarker for early breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24922658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24922658"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ya-Ching Lu, Joseph T Chang, Chun-Ta Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-218"}], "href": "https://doi.org/10.1186/1476-4598-13-218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25233933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25233933"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ya-Ching Lu, Joseph Tung-Chieh Chang, Yu-Chen Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinbiochem.2014.11.020"}], "href": "https://doi.org/10.1016/j.clinbiochem.2014.11.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25485932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25485932"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yae-Eun Suh, Nina Raulf, Joop Gäken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-196a promotes an oncogenic effect in head and neck cancer cells by suppressing annexin A1 and enhancing radioresistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.29397"}], "href": "https://doi.org/10.1002/ijc.29397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25523631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25523631"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Lav Darda, Fahad Hakami, Richard Morgan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0122285"}], "href": "https://doi.org/10.1371/journal.pone.0122285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25860510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25860510"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yi Fan, Jin Fan, Liu Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of microRNA-196a predicts poor prognosis in human ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26097603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26097603"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yanlei Guan, Ling Chen, Yijun Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High miR-196a and low miR-367 cooperatively correlate with unfavorable prognosis of high-grade glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26261539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26261539"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yoon Suk Lee, Haeryoung Kim, Hyoung Woo Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High Expression of MicroRNA-196a Indicates Poor Prognosis in Resected Pancreatic Neuroendocrine Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000002224"}], "href": "https://doi.org/10.1097/MD.0000000000002224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26683934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26683934"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "P Liu, F Xin, C F Ma "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2015.December.22.25"}], "href": "https://doi.org/10.4238/2015.December.22.25"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26782446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26782446"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yi Yuan, Durkeshwari Anbalagan, Lay Hoon Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8875"}], "href": "https://doi.org/10.18632/oncotarget.8875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27105503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27105503"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jingjing Pan, Xu Li, Wenjing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.08.015"}], "href": "https://doi.org/10.1016/j.canlet.2016.08.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27591936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27591936"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Wenwu Yang, Li Hong, Xuexian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317711315"}], "href": "https://doi.org/10.1177/1010428317711315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28671039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28671039"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kai Wang, Juan Li, Gang Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of lncRNA GAS5 by miR-196a inhibits esophageal squamous cell carcinoma growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.11.119"}], "href": "https://doi.org/10.1016/j.bbrc.2017.11.119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29170131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29170131"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Liping Wang, Yongxiang Wei, Yongyong Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.6174"}], "href": "https://doi.org/10.3892/or.2017.6174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29286141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29286141"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Shuqin Li, Jun Zhou, Zhaoxin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of proliferation and invasion by competitively binding miR-196a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.05.056"}], "href": "https://doi.org/10.1016/j.biopha.2018.05.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29793177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29793177"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Weihua Ren, Shuangting Wu, Yabin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-196a/-196b regulate the progression of hepatocellular carcinoma through modulating the JAK/STAT pathway via targeting SOCS2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1530-4"}], "href": "https://doi.org/10.1038/s41419-019-1530-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30988277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30988277"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Minghao Liu, Yiqi Du, Jun Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant expression miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pancreas (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPA.0b013e3182962acb"}], "href": "https://doi.org/10.1097/MPA.0b013e3182962acb"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24048456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24048456"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yeon Jeong Kim, Sang Woo Bae, Sung Sook Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1359/jbmr.081230"}], "href": "https://doi.org/10.1359/jbmr.081230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19063684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19063684"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Weihong Hou, Qing Tian, Jianyu Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.23401"}], "href": "https://doi.org/10.1002/hep.23401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20127796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20127796"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Masaki Mori, Hironori Nakagami, Gerardo Rodriguez-Araujo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for miR-196a in brown adipogenesis of white fat progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1001314"}], "href": "https://doi.org/10.1371/journal.pbio.1001314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22545021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22545021"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Jiao Meng, Limin Li, Yue Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-196a/b Mitigate Renal Fibrosis by Targeting TGF-β Receptor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2015040422"}], "href": "https://doi.org/10.1681/ASN.2015040422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26940097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26940097"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Lu-Shiun Her, Su-Han Mao, Chih-Yi Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.18813"}], "href": "https://doi.org/10.7150/thno.18813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28744327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28744327"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Changming Zhang, Shaoshan Liang, Shuiqin Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary miR-196a predicts disease progression in patients with chronic kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-018-1470-2"}], "href": "https://doi.org/10.1186/s12967-018-1470-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29636065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29636065"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Feng Zhong, Wei Zhang, Yang Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NEAT1 promotes colorectal cancer cell proliferation and migration via regulating glial cell-derived neurotrophic factor by sponging miR-196a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmy130"}], "href": "https://doi.org/10.1093/abbs/gmy130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30383193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30383193"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Ling Zhang, Haiqin Xie, Shiliang Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LOXL1-AS1 controls osteogenic and adipocytic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis through regulating the miR-196a-5p/Hmga2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00774-020-01123-z"}], "href": "https://doi.org/10.1007/s00774-020-01123-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32651705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32651705"}]}]}]}