{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐197 is a versatile regulatory microRNA implicated in multiple human diseases. In several solid tumors, miR‐197 acts as a critical modulator of cancer cell behavior. For instance, in pancreatic cancer, increased levels of miR‐197 induce epithelial–mesenchymal transition by targeting p120 catenin, thereby promoting invasion and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In oral squamous cell carcinoma, miR‐197 is integrated in a competing endogenous RNA network involving lncRNA SNHG20 and LIN28 that affects cellular proliferation and stemness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in bladder cancer, miR‐197–3p is modulated by long noncoding RNAs such as LINC00641 and LINC00312 to regulate tumor suppressors like KLF10 and impact the PTEN/PI3K/AKT pathway as well as cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In non–small cell lung and prostate cancers, distinct isoforms of miR‐197 (e.g. miR‐197–3p) target molecules including p120 catenin and VDAC1, contributing respectively to chemoresistance and tumor‐suppressive signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hematologic malignancies, miR‐197’s tumor‐suppressive role is further underscored. Its deregulation has been associated with multiple myeloma, where it may help counterbalance oncogenic signals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and in Burkitt lymphoma, cellular miR‐197 collaborates with Epstein–Barr virus–derived miRNAs to regulate key inflammatory receptors such as IL‐1β receptor type I."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of viral infection, miR‐197 is downregulated by enterovirus 71, which leads to the derepression of the host protein RAN—a factor that facilitates viral replication—thereby highlighting a mechanism by which viruses may subvert normal cellular control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nmiR‐197 also contributes to the regulation of the tumor microenvironment and influences metastasis in diverse settings. In glioma, for example, a regulatory axis involving lncRNA DLX6‐AS1 and miR‐197–5p modulates E2F1 expression and thereby impacts tumor progression, while distinct circular RNAs (such as circ_0029426) have been shown to sponge miR‐197, affecting glioma cell behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Exosomal miR‐197–3p in nasopharyngeal carcinoma has been demonstrated to modulate radioresistance by targeting the endoplasmic reticulum chaperone HSPA5 and subsequently influencing the AKT/mTOR pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and a similar exosome‐mediated mechanism in lung adenocarcinoma promotes angiogenesis and metastasis via the inhibition of TIMP2 and TIMP3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Moreover, in glioblastoma, upregulation of miR‐197 by FUS1 contributes to suppressing tumor growth and invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumorigenesis, miR‐197 serves as a valuable circulating biomarker. In cardiovascular disease, circulating miR‐197 is involved in endovascular inflammation and platelet activation, suggesting its potential for diagnosis in coronary artery disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Similarly, altered miR‐197 expression in non–small cell lung cancer correlates with prognosis and risk stratification for brain metastases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nmiR‐197 further modulates the response to chemotherapeutics. In colorectal cancer, its downregulation following exposure to 5‐fluorouracil (5‐FU) contributes to drug resistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", while in gastric cancer, miR‐197 targeting of MAPK1 is implicated in the modulation of 5‐FU sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Additionally, a regulatory axis involving the lncRNA JPX and miR‐197 affects autophagy and cell migration via modulation of CXCR6, further impacting gastric cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other tumor types and pathological conditions, miR‐197 exerts tumor‐suppressive functions. In fibrosarcoma, overexpression of miR‐197–5p induces cellular senescence and curtails metastatic behavior by targeting KIAA0101."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Furthermore, in the context of developmental defects, differential binding of miR‐197 to allelic variants in the 3′UTR of MTHFD1L may influence the risk of neural tube defects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": " In autoinflammatory diseases such as familial Mediterranean fever, miR‐197–3p exerts anti‐inflammatory effects by directly targeting IL‐1β receptor, thereby modulating the inflammatory cascade."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, modulation of miR‐197 expression has been linked to alterations in lipid metabolism. Silencing of STAT6 results in downregulation of miR‐197, which in turn affects FOXJ2 expression and alters cholesterol biosynthesis, highlighting an additional layer of metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shin Hamada, Kennichi Satoh, Shin Miura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24280"}], "href": "https://doi.org/10.1002/jcp.24280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23139153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23139153"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Wu, Wei Zhao, Zhonghou Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13987"}], "href": "https://doi.org/10.1111/jcmm.13987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30394668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30394668"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhijia Li, Shizhe Hong, Zhihu Liu "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00641 predicts prognosis and inhibits bladder cancer progression through miR-197-3p/KLF10/PTEN/PI3K/AKT cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.07.120"}], "href": "https://doi.org/10.1016/j.bbrc.2018.07.120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30060954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30060954"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yun-Yan Wang, Zi-Yu Wu, Gong-Cheng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-5303-8"}], "href": "https://doi.org/10.1007/s13277-016-5303-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27631965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27631965"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tian Yang, Hong Li, Tianjun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MALAT1 Depressed Chemo-Sensitivity of NSCLC Cells through Directly Functioning on miR-197-3p/p120 Catenin Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2019.2364"}], "href": "https://doi.org/10.14348/molcells.2019.2364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30841025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30841025"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiang Huang, Bo Ma, Yixi Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-197-3p Represses the Proliferation of Prostate Cancer by Regulating the VDAC1/AKT/β-catenin Signaling Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.42019"}], "href": "https://doi.org/10.7150/ijbs.42019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32210729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32210729"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yijun Yang, Fei Li, Manujendra N Saha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple Myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-14-1437"}], "href": "https://doi.org/10.1158/1078-0432.CCR-14-1437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25724519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25724519"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yang-Min Zhang, Yan Yu, He-Ping Zhao "}, {"type": "b", "children": [{"type": "t", "text": "EBV‑BART‑6‑3p and cellular microRNA‑197 compromise the immune defense of host cells in EBV‑positive Burkitt lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.6173"}], "href": "https://doi.org/10.3892/mmr.2017.6173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28259992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28259992"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wen-Fang Tang, Ru-Ting Huang, Kun-Yi Chien, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02143-15"}], "href": "https://doi.org/10.1128/JVI.02143-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26581983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26581983"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiangpan Li, Huibo Zhang, Xiaofei Wu "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA DLX6-AS1 accelerates the glioma carcinogenesis by competing endogenous sponging miR-197-5p to relieve E2F1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.10.065"}], "href": "https://doi.org/10.1016/j.gene.2018.10.065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30366080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30366080"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Guifang Zhang, Weibo Sun, Liangfu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR-197."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28313"}], "href": "https://doi.org/10.1002/jcb.28313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30548670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30548670"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jiahui Jiang, Qiao Tang, Jiaoe Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Radiosensitizer EXO-miR-197-3p Inhibits Nasopharyngeal Carcinoma Progression and Radioresistance by Regulating the AKT/mTOR Axis and HSPA5-mediated Autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.69934"}], "href": "https://doi.org/10.7150/ijbs.69934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35342334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35342334"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rui-Min Chang, Yao Fu, Jun Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-derived exosomal miR-197-3p confers angiogenesis via targeting TIMP2/3 in lung adenocarcinoma metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05420-5"}], "href": "https://doi.org/10.1038/s41419-022-05420-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36494333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36494333"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jun Xin, Xue-Kui Zhang, De-You Xin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4069"}], "href": "https://doi.org/10.3892/or.2015.4069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26081814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26081814"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Christian Schulte, Simon Molz, Sebastian Appelbaum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0145930"}], "href": "https://doi.org/10.1371/journal.pone.0145930"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26720041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26720041"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "K Mavridis, F Gueugnon, A Petit-Courty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oncomiR miR-197 is a novel prognostic indicator for non-small cell lung cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2015.119"}], "href": "https://doi.org/10.1038/bjc.2015.119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25867273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25867273"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "J Remon, D Alvarez-Berdugo, M Majem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-197 and miRNA-184 are associated with brain metastasis in EGFR-mutant lung cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-015-1347-2"}], "href": "https://doi.org/10.1007/s12094-015-1347-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26199015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26199015"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Z Sun, N Zhou, Q Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-197 influences 5-fluorouracil resistance via thymidylate synthase in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-015-1318-7"}], "href": "https://doi.org/10.1007/s12094-015-1318-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26055341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26055341"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hai-Lin Xiong, Si-Wei Zhou, Ai-Hua Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑197 reverses the drug resistance of fluorouracil‑induced SGC7901 cells by targeting mitogen‑activated protein kinase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.4052"}], "href": "https://doi.org/10.3892/mmr.2015.4052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26151540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26151540"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xuejing Han, Zheng Liu "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11698"}], "href": "https://doi.org/10.3892/mmr.2020.11698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33215222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33215222"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Neha Jain, Jyoti Roy, Basudeb Das, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-197-5p inhibits sarcomagenesis and induces cellular senescence via repression of KIAA0101."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23021"}], "href": "https://doi.org/10.1002/mc.23021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31001891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31001891"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Stefano Minguzzi, S Duygu Selcuklu, Charles Spillane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An NTD-associated polymorphism in the 3' UTR of MTHFD1L can affect disease risk by altering miRNA binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22459"}], "href": "https://doi.org/10.1002/humu.22459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24123340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24123340"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yeliz Z Akkaya-Ulum, Tayfun Hilmi Akbaba, Zeynep Tavukcuoglu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-80097-4"}], "href": "https://doi.org/10.1038/s41598-020-80097-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33436947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33436947"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Richa Dubey, Neeru Saini "}, {"type": "b", "children": [{"type": "t", "text": "STAT6 silencing up-regulates cholesterol synthesis via miR-197/FOXJ2 axis and induces ER stress-mediated apoptosis in lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2014.10.002"}], "href": "https://doi.org/10.1016/j.bbagrm.2014.10.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25451482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25451482"}]}]}]}