MIR1972-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 1972-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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This pro‑angiogenic role implicates miR‑1972 in pannus formation and the progression of joint inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui-min Fan, Xin-yang Sun, Wei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatr Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpsychires.2014.08.007"}], "href": "https://doi.org/10.1016/j.jpsychires.2014.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25201637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25201637"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wen-Qing Huang, Qing Lin, Shuai Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of microRNA and mRNA expression profiling identifies "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "BAIAP3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as a novel target of dysregulated hsa-miR-1972 in age-related white matter lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202562"}], "href": "https://doi.org/10.18632/aging.202562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33561007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33561007"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu Jin, Ye Shen Wong, Brian K P Goh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-46872-8"}], "href": "https://doi.org/10.1038/s41598-019-46872-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31320713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31320713"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sonja Ludwig, Priyanka Sharma, Petra Wise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mRNA and miRNA Profiles of Exosomes from Cultured Tumor Cells Reveal Biomarkers Specific for HPV16-Positive and HPV16-Negative Head and Neck Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21228570"}], "href": "https://doi.org/10.3390/ijms21228570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33202950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33202950"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yixiong Chen, Junlong Dang, Xiaorong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RA Fibroblast-Like Synoviocytes Derived Extracellular Vesicles Promote Angiogenesis by miRNA-1972 Targeting p53/mTOR Signaling in Vascular Endotheliocyte."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.793855"}], "href": "https://doi.org/10.3389/fimmu.2022.793855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35350778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35350778"}]}]}]}
Synonyms HSA-MIR-1972, HSA-MIR-1972-1, MIR1972
NCBI Gene ID 100302243
API
Download Associations
Predicted Functions View MIR1972-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1972-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1972-1's ARCHS4 Predicted Functions.

Functional Associations

MIR1972-1 has 177 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR1972-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1972-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1972-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1972-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1972-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1972-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1972-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1972-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1972-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.