MIR1972-2 Gene

HGNC Family Non-coding RNAs
Name microRNA 1972-2
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research in head and neck cancer has demonstrated a distinct molecular signature in exosomes derived from cancer cells based on human papillomavirus (HPV) status. In particular, miR-1972 was uniquely detected in exosomes from HPV‐negative cells, suggesting that this microRNA may serve as a discriminating biomarker to distinguish HPV(–) tumors and potentially refine molecular classification in head and neck cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate study addressing rheumatoid arthritis (RA), extracellular vesicles released by fibroblast-like synoviocytes were shown to promote angiogenesis in endothelial cells via miR-1972. Here, miR-1972 facilitates key angiogenic processes including endothelial cell migration and tube formation by modulating the p53/mTOR signaling pathway—evidenced by decreased p53 levels and increased phosphorylated mTOR—thus positioning miR-1972 as a promising therapeutic target to mitigate pathological angiogenesis in RA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sonja Ludwig, Priyanka Sharma, Petra Wise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mRNA and miRNA Profiles of Exosomes from Cultured Tumor Cells Reveal Biomarkers Specific for HPV16-Positive and HPV16-Negative Head and Neck Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21228570"}], "href": "https://doi.org/10.3390/ijms21228570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33202950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33202950"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yixiong Chen, Junlong Dang, Xiaorong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RA Fibroblast-Like Synoviocytes Derived Extracellular Vesicles Promote Angiogenesis by miRNA-1972 Targeting p53/mTOR Signaling in Vascular Endotheliocyte."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.793855"}], "href": "https://doi.org/10.3389/fimmu.2022.793855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35350778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35350778"}]}]}]}
NCBI Gene ID 100422922
API
Download Associations
Predicted Functions View MIR1972-2's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1972-2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1972-2's ARCHS4 Predicted Functions.

Functional Associations

MIR1972-2 has 173 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 6 datasets.

Click the + buttons to view associations for MIR1972-2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1972-2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1972-2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1972-2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1972-2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1972-2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1972-2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.