MIR1976 Gene

HGNC Family Non-coding RNAs
Name microRNA 1976
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn lung cancers, including non‐small cell lung cancer (NSCLC) and lung adenocarcinoma (LUAD), miR‑1976 functions as a tumor suppressor by targeting key oncogenic molecules. In NSCLC, miR‑1976 expression is markedly reduced, and its overexpression inhibits cellular growth and metastasis through direct suppression of phospholipase C epsilon 1 (PLCE1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in LUAD, miR‑1976 directly binds to the 3′ untranslated region of NCAPH, thereby decreasing NCAPH expression, reducing cell proliferation and migration, and promoting apoptosis via inhibition of NF‑κB signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cardiovascular system, particularly in age‑related sick sinus syndrome (SSS), miR‑1976 is upregulated and contributes to sinoatrial node degeneration. Elevated miR‑1976 levels correlate with decreased expression of the Cav1.2 and Cav1.3 Ca2+ channels, leading to reduced intrinsic heart rates and prolonged corrective sinus recovery times. These findings position miR‑1976 as both a potential noninvasive biomarker and a therapeutic target for managing SSS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of breast cancer, miR‑1976 has been linked to disease progression and metastasis. In triple‐negative breast cancer, diminished expression of miR‑1976 is associated with enhanced epithelial‑mesenchymal transition (EMT) and cancer stem cell properties via derepression of phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit gamma (PIK3CG)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, altered levels of miR‑1976 detected in plasma samples from breast cancer patients further support its clinical utility as a diagnostic and prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gang Chen, Jing Hu, Zhao Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1976 functions as a tumor suppressor and serves as a prognostic indicator in non-small cell lung cancer by directly targeting PLCE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.04.030"}], "href": "https://doi.org/10.1016/j.bbrc.2016.04.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27063799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27063799"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peiluo Huang, Hongtao Zhao, Ruonan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1976/NCAPH/P65 axis inhibits the malignant phenotypes of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-61261-6"}], "href": "https://doi.org/10.1038/s41598-024-61261-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38755247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38755247"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jin Zhang, Feiyu Wei, Liqun Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "v"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "1.2 and Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "v"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "1.3 ion channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2019.06.018"}], "href": "https://doi.org/10.1016/j.yjmcc.2019.06.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31302118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31302118"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jingyi Wang, Minghui Li, Xu Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1976 knockdown promotes epithelial-mesenchymal transition and cancer stem cell properties inducing triple-negative breast cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2711-x"}], "href": "https://doi.org/10.1038/s41419-020-2711-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32620748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32620748"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "J Wang, G Ma, X Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The low expression of miR-1976 in plasma samples indicating its biological functions in the progression of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-020-02361-3"}], "href": "https://doi.org/10.1007/s12094-020-02361-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32419112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32419112"}]}]}]}
Synonyms HSA-MIR-1976
NCBI Gene ID 100302190
API
Download Associations
Predicted Functions View MIR1976's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1976's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1976's ARCHS4 Predicted Functions.

Functional Associations

MIR1976 has 342 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR1976 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1976 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1976 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1976 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1976 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1976 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1976 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR1976 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1976 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1976 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1976 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.