{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR199A2 is a critical genomic locus that encodes miR‐199a, which is processed into two mature species (miR‐199a‐3p and miR‐199a‐5p) that play multifaceted roles in cell biology. In ovarian cancer, for example, miR‐199a regulates inflammatory and protumor pathways by directly targeting IKKβ and by modulating NF‐κB and PTEN/AKT signaling; it also contributes to cancer stem cell differentiation and tissue homeostasis, as evidenced by its roles in processes such as myometrial quiescence. These findings underscore an important function for MIR199A2 in the regulation of “stemness” and differentiation in both malignant and normal tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diverse malignancies, MIR199A2 exhibits context‐dependent functions that can either restrain or promote tumor progression. In hepatocellular carcinoma, miR‐199a‐3p reduces cell proliferation and chemoresistance by downregulating targets such as CD44 and RGS17, while re‐expression in osteosarcoma suppresses cell growth and migration. In gastric and colorectal cancers, aberrant expression of miR‐199a correlates with enhanced metastasis, and in cutaneous squamous cell and breast cancers, miR‐199a controls key regulators of the epithelial–mesenchymal transition (including E‐cadherin and PAK4). These studies collectively reveal that miR‐199a plays a pivotal role in modulating oncogenic signaling, invasion, and drug sensitivity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIR199A2 also influences the tumor microenvironment and cellular metabolism. In endothelial cells, miR‐199a‐5p restricts angiogenic responses by directly targeting transcription factors such as Ets‐1, while in multiple myeloma, its re‐expression decreases GRP78 levels and overcomes chemoresistance. Furthermore, miR‐199a is involved in endoplasmic reticulum stress responses in hepatic cells and contributes to the metabolic reprogramming of hepatocellular carcinoma through hypoxia‐responsive mechanisms. A role in stromal modulation is evident from studies showing that exosome‐mediated transfer of miR‐199a in pancreatic stellate cells and in ischemic stroke models regulates fibrogenesis and cell–cell interactions, thereby emphasizing its importance in non–cell autonomous regulation within the tumor milieu."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its established roles in cancer, altered MIR199A2 expression is emerging as a promising biomarker and functional modulator in several non‐malignant conditions. Elevated miR‐199a levels have been linked to chondrocyte senescence in osteoarthritis, while aberrant circulating levels serve as diagnostic indicators in early gastric and colorectal cancers. In testicular germ cell tumors, miR‐199a‐3p targets the de novo methyltransferase DNMT3A to restore tumor suppressor gene expression, and its impact on monocyte/macrophage differentiation suggests roles in immune regulation. Moreover, preliminary evidence hints at involvement in conditions such as chondrosarcoma and ankylosing spondylitis, thereby broadening the therapeutic implications of targeting MIR199A2."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R Chen, A B Alvero, D A Silasi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7651"}], "href": "https://doi.org/10.18632/oncotarget.7651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26918939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26918939"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Li Chen, Ruju Chen, Victoria M Velazquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibrogenic Signaling Is Suppressed in Hepatic Stellate Cells through Targeting of Connective Tissue Growth Factor (CCN2) by Cellular or Exosomal MicroRNA-199a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2016.07.011"}], "href": "https://doi.org/10.1016/j.ajpath.2016.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27662798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27662798"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Zhengfeng Wang, Ruihua Wang, Kai Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated long noncoding RNA Snhg1 promotes the angiogenesis of brain microvascular endothelial cells after oxygen-glucose deprivation treatment by targeting miR-199a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Can J Physiol Pharmacol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/cjpp-2018-0107"}], "href": "https://doi.org/10.1139/cjpp-2018-0107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29883549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29883549"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Simona Zanotti, Sara Gibertini, Flavia Blasevich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes and exosomal miRNAs from muscle-derived fibroblasts promote skeletal muscle fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2018.07.003"}], "href": "https://doi.org/10.1016/j.matbio.2018.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29981373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29981373"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Nahid Akhtar, Tariq M Haqqi "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2011-200519"}], "href": "https://doi.org/10.1136/annrheumdis-2011-200519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22294637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22294637"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Taku Ukai, Masato Sato, Hidenori Akutsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jor.22157"}], "href": "https://doi.org/10.1002/jor.22157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22674437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22674437"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Shen Gu, Wai-Yee Chan "}, {"type": "b", "children": [{"type": "t", "text": "Flexible and versatile as a chameleon-sophisticated functions of microRNA-199a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms13078449"}], "href": "https://doi.org/10.3390/ijms13078449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22942713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22942713"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Chen Li, Jian Fang Li, Qu Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-199a-3p: A potential circulating diagnostic biomarker for early gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Surg Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jso.23358"}], "href": "https://doi.org/10.1002/jso.23358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23733518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23733518"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Bi-Feng Chen, Shen Gu, Yick-Keung Suen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.25799"}], "href": "https://doi.org/10.4161/epi.25799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23959088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23959088"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Hai-Shuang Lin, Jia-Nan Gong, Rui Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPα expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.1A0514-240R"}], "href": "https://doi.org/10.1189/jlb.1A0514-240R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25258381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25258381"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Ryoji Nonaka, Junichi Nishimura, Yoshinori Kagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-199a-3p as a novel serum biomarker for colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3515"}], "href": "https://doi.org/10.3892/or.2014.3515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25269744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25269744"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Guan-Ting Liu, Yuan-Li Huang, Huey-En Tzeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.11.015"}], "href": "https://doi.org/10.1016/j.canlet.2014.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25444917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25444917"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Wentong Li, Hui Wang, Jinbao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-199a-5p regulates β1 integrin through Ets-1 to suppress invasion in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12952"}], "href": "https://doi.org/10.1111/cas.12952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27094578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27094578"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Yahan Wang, Jianping Luo, Xiaogang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-199a-5p Induced Autophagy and Inhibits the Pathogenesis of Ankylosing Spondylitis by Modulating the mTOR Signaling via Directly Targeting Ras Homolog Enriched in Brain (Rheb)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000480211"}], "href": "https://doi.org/10.1159/000480211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28848090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28848090"}]}]}]}