{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNA MIR2052HG plays a dual regulatory role in maintaining estrogen receptor α (ERα) levels in breast cancer cells by promoting ESR1 transcription through AKT/FOXO3 signaling and by limiting its ubiquitin-mediated degradation. These functions were initially highlighted through a genome‐wide association study that identified SNPs in MIR2052HG associated with breast cancer–free intervals in patients receiving aromatase inhibitor therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have explored the clinical implications of MIR2052HG, particularly its association with breast cancer resistance and recurrence. Pharmacokinetic investigations suggest that variants within this lncRNA may influence patient prognosis, although the precise mechanistic links between MIR2052HG SNPs and breast cancer development continue to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, emerging research is examining whether genetic variations in MIR2052HG contribute not only to the onset and progression of breast cancer via its role in sustaining ERα levels but also to reproductive disorders such as recurrent miscarriage. Although the association of the MIR2052HG rs3802201 C>G polymorphism with recurrent abortion risk remains to be definitively determined, this line of inquiry underscores the broader biological significance of MIR2052HG across different disease contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junmei Cairns, James N Ingle, Krishna R Kalari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13058-019-1130-3"}], "href": "https://doi.org/10.1186/s13058-019-1130-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30944027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30944027"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Yang, Qiuyu Sun, Feifei Chong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in lncRNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MIR2052HG"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and susceptibility to breast cancer in Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203686"}], "href": "https://doi.org/10.18632/aging.203686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34762068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34762068"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hanran Mai, Canhong Cai, Kun Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24167"}], "href": "https://doi.org/10.1002/jcla.24167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34910326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34910326"}]}]}]}