{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have evaluated serum RNA biomarker panels for aggressive cancers, including malignant pleural mesothelioma (MPM), where specific RNA molecules are explored for their diagnostic and prognostic utility. In one study, miR-2053 was among the circulating RNAs profiled in patient sera, suggesting its potential, albeit not fully defined, role in the context of MPM biomarker panels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn esophageal cancer, miR-2053 has been functionally characterized and found to be downregulated in cancer cell lines. Restoration via overexpression of miR-2053 resulted in reduced cell proliferation, migration, and invasion, while simultaneously promoting apoptosis. These effects were mediated, at least in part, through the attenuation of epithelial–mesenchymal transition (EMT) and upregulation of pro-apoptotic proteins. Mechanistically, miR-2053 suppresses the expression of KIF3C and interferes with the PI3K/AKT signaling pathway, highlighting its tumor‐suppressive function. This work builds on broader research into microRNAs in esophageal carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its implications in cancer, miR-2053 also appears to play a regulatory role in non-neoplastic disease. In ulcerative colitis, a genetic variant (rs6214 C > T) within the insulin-like growth factor-1 (IGF-1) gene enhances the binding of miR-2053, leading to downregulated IGF-1 expression and an increased risk of disease severity. This finding underscores miR-2053's potential as a modulator of inflammatory disease processes and indicates its promise as a target for prognostic and therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marwa Matboli, Ayman E Shafei, Mahmoud A Ali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of serum DRAM1 mRNA, ARSA mRNA, hsa-miR-2053 and lncRNA-RP1-86D1.3 axis expression in malignant pleural mesothelioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27586"}], "href": "https://doi.org/10.1002/jcb.27586"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30362153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30362153"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenjian Yao, Xiangbo Jia, Lei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-2053 involves in the progression of esophageal cancer by targeting KIF3C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1929675"}], "href": "https://doi.org/10.1080/15384101.2021.1929675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34057012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34057012"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bin Wang, Li Zhang, Jindong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-019-06015-5"}], "href": "https://doi.org/10.1007/s10620-019-06015-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894485"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huiping Wang, Jin Wang, Chunsong Geng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A variant rs6214 within IGF-1 confers risk for ulcerative colitis in Chinese Han populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-022-00921-0"}], "href": "https://doi.org/10.1007/s10142-022-00921-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36520299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36520299"}]}]}]}