| Name | MIR205 host gene |
| Description | Predicted to be involved in several processes, including hormone biosynthetic process; prolactin metabolic process; and regulation of DNA-binding transcription factor activity. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR205HG is emerging as an oncogenic long noncoding RNA that contributes to tumor progression in several cancer types. In cervical cancer, MIR205HG is significantly upregulated, where it acts as a competing endogenous RNA (ceRNA) that sponges microRNAs (e.g., miR‑122‑5p) to upregulate targets such as FOXP2, thereby promoting cell proliferation and metastasis. In addition, MIR205HG modulates alternative splicing regulatory networks by depleting SRSF1, which in turn elevates KRT17 expression and enhances cell growth and migration. (See"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ")\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung squamous cell carcinoma (LUSC), MIR205HG is also upregulated and correlates with increased malignancy, where it supports tumor cell growth and migration by regulating apoptotic factors (Bcl‑2 and Bax) to avoid cell death. In melanoma, MIR205HG sustains tumor progression via distinct mechanisms: it binds and sponges miR‑299‑3p, thereby elevating VEGFA expression, and it interacts with the RNA‐binding protein HuR to stabilize JMJD2C transcripts; the latter activity promotes ALKBH5 transcription by modulating histone methylation patterns. (See"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ")\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to its upregulation in several malignancies, MIR205HG is downregulated in esophageal carcinoma, where its decreased expression is associated with enhanced cell migration and invasion through a mechanism involving interaction with HNRNPA0 and LIN28A that interferes with extracellular matrix gene regulation. Lastly, while MIR205HG has been investigated in multiple cancers, its role in hepatoblastoma remains to be elucidated, suggesting a potential avenue for future research. (See"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ")\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yishu Li, Hongying Wang, Huijuan Huang "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MIR205HG function as a ceRNA to accelerate tumor growth and progression via sponging miR-122-5p in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.04.102"}], "href": "https://doi.org/10.1016/j.bbrc.2019.04.102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31023531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31023531"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingli Dong, Zhennan Dong, Xinyu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MIR205HG regulates KRT17 and tumor processes in cervical cancer via interaction with SRSF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2019.104322"}], "href": "https://doi.org/10.1016/j.yexmp.2019.104322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31655037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31655037"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Chang, Xinying Xue, Chunsun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR205HG facilitates carcinogenesis of lung squamous cell carcinoma in vitro revealed by long noncoding RNA profiling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmaa006"}], "href": "https://doi.org/10.1093/abbs/gmaa006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32188965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32188965"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jinlan Guo, Quan Gan, Caibin Gan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MIR205HG regulates melanomagenesis via the miR-299-3p/VEGFA axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202450"}], "href": "https://doi.org/10.18632/aging.202450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33535182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33535182"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yujing Liu, Suihai Wang, Shanshan Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0290986"}], "href": "https://doi.org/10.1371/journal.pone.0290986"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38252669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38252669"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoying Dong, Xuyuan Chen, Di Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA miR205HG hinders HNRNPA0 translation: anti-oncogenic effects in esophageal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.13142"}], "href": "https://doi.org/10.1002/1878-0261.13142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34821009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34821009"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wei Zhang, Feng Liang, Qingfeng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Direct (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13062-021-00309-3"}], "href": "https://doi.org/10.1186/s13062-021-00309-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34996511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34996511"}]}]}]}
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| Synonyms | NPC-A-5, LINC00510 |
| NCBI Gene ID | 642587 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR205HG has 880 functional associations with biological entities spanning 7 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 28 datasets.
Click the + buttons to view associations for MIR205HG from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MIR205HG gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MIR205HG gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR205HG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR205HG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR205HG gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR205HG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR205HG gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR205HG gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR205HG gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR205HG gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MIR205HG gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MIR205HG gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MIR205HG gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MIR205HG gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MIR205HG gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MIR205HG gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MIR205HG gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MIR205HG gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with MIR205HG gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with MIR205HG gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with MIR205HG gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR205HG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with MIR205HG gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MIR205HG protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by MIR205HG gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR205HG gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR205HG gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MIR205HG gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
