{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐20b is emerging as a multifaceted regulator in tumor biology where its function appears strongly context‐dependent. In several cancer types—including breast, colorectal, bladder, renal, osteosarcoma, glioblastoma, papillary thyroid carcinoma, Ewing’s sarcoma, and others—miR‐20b has been implicated in modulating key processes such as cell proliferation, migration, invasion, and stemness. In some settings, miR‐20b acts to suppress angiogenic factors (for example, by inhibiting vascular endothelial growth factor in breast cancer) and is involved in cell‐cycle arrest and autophagy through targeting regulators like RB1CC1/FIP200, whereas in other contexts its upregulation enhances oncogenic signaling by repressing tumor suppressors (for instance, inhibiting PTEN and BRCA1) or by targeting receptors such as TGF‐β receptor 2. Moreover, miR‐20b has been shown to impact chemoresistance—for example, mitigating resistance to taxol and 5‐fluorouracil—and to participate in subtype‐specific regulatory circuits in glioblastoma and other malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in neoplasia, miR‐20b also functions in diverse non‐malignant settings by modulating inflammatory, immune, vascular, and neural processes. In models of diabetic complications, for example, altered levels of miR‐20b affect angiogenesis and vascular permeability in retinal endothelial cells and impair wound healing via regulation of pathways such as Wnt/β‐catenin and AKT3. Likewise, in infectious and autoimmune conditions—including tuberculosis and myasthenia gravis—miR‐20b influences the inflammatory response through direct targeting of key molecules like NLRP3, as well as by modulating cytokine expression (eg, IL‐8 and IL‐25). In addition, its ability to regulate iron homeostasis by targeting ferroportin and to modulate neuronal markers such as the amyloid precursor protein highlights a broader physiological significance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "40"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nImportantly, modulation of miR‐20b levels holds therapeutic promise. In cancer models, restoration or inhibition of miR‐20b expression has been shown to reverse drug resistance—enhancing sensitivity to agents such as taxol, 5‐fluorouracil, and even radiotherapy (in combination with immune checkpoint blockade)—by re‐balancing oncogenic and tumor‐suppressive networks. These observations, together with its emerging role as a circulating diagnostic biomarker in several tumors, underline miR‐20b’s potential as both a prognostic indicator and a target for intervention in a broad spectrum of diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandra Cascio, Aleco D'Andrea, Rita Ferla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22126"}], "href": "https://doi.org/10.1002/jcp.22126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20232316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20232316"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angela B Y Hui, Alice Lin, Wei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-12-3572"}], "href": "https://doi.org/10.1158/1078-0432.CCR-12-3572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23459718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23459718"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dongping Li, Yaroslav Ilnytskyy, Anna Kovalchuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1165"}], "href": "https://doi.org/10.18632/oncotarget.1165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23945289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23945289"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Amina Saleiban, Lars Faxälv, Kjersti Claesson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-20b regulates expression of proteinase-activated receptor-1 (PAR-1) thrombin receptor in melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pigment Cell Melanoma Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/pcmr.12217"}], "href": "https://doi.org/10.1111/pcmr.12217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24405508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24405508"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jianjie Zhu, Lanxin Chen, Lingting Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humimm.2014.01.006"}], "href": "https://doi.org/10.1016/j.humimm.2014.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24468585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24468585"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zeyong Jiang, Jun Yin, Wenfan Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA 17 family regulates cisplatin-resistant and metastasis by targeting TGFbetaR2 in NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0094639"}], "href": "https://doi.org/10.1371/journal.pone.0094639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24722426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24722426"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tatsuro Yamaguchi, Takeru Iijima, Rika Wakaume, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Underexpression of miR-126 and miR-20b in hereditary and nonhereditary colorectal tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000363303"}], "href": "https://doi.org/10.1159/000363303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24994098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24994098"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sung Lyea Park, Tae-Min Cho, Se Yeon Won, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-20b inhibits the proliferation, migration and invasion of bladder cancer EJ cells via the targeting of cell cycle regulation and Sp-1-mediated MMP-2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4119"}], "href": "https://doi.org/10.3892/or.2015.4119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26166554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26166554"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yifan Li, Duqun Chen, Lu Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-20b-5p functions as a tumor suppressor in renal cell carcinoma by regulating cellular proliferation, migration and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.4692"}], "href": "https://doi.org/10.3892/mmr.2015.4692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26708577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26708577"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shufeng Li, Qian Qiang, Haitao Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2016.01.044"}], "href": "https://doi.org/10.1016/j.lfs.2016.01.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26829385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26829385"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ming Liu, Dan Wang, Ning Li "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-20b Downregulates HIF-1α and Inhibits the Proliferation and Invasion of Osteosarcoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14562725373752"}], "href": "https://doi.org/10.3727/096504016X14562725373752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27098149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27098149"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tianzhi Huang, Angel A Alvarez, Rajendra P Pangeni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12885"}], "href": "https://doi.org/10.1038/ncomms12885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27698350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27698350"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shubin Hong, Shuang Yu, Jin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20b Displays Tumor-Suppressor Functions in Papillary Thyroid Carcinoma by Regulating the MAPK/ERK Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2015.0578"}], "href": "https://doi.org/10.1089/thy.2015.0578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27717302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27717302"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiang Ao, Peipei Nie, Baoyan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2016.367"}], "href": "https://doi.org/10.1038/cddis.2016.367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27831559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27831559"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yanzhong Xin, Hongfei Cai, Tianyu Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-20b Inhibits T Cell Proliferation and Activation via NFAT Signaling Pathway in Thymoma-Associated Myasthenia Gravis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2016/9595718"}], "href": "https://doi.org/10.1155/2016/9595718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27833920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27833920"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Qiang Fu, Jing Cheng, Jindai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-20b reduces 5-FU resistance by suppressing the ADAM9/EGFR signaling pathway in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5259"}], "href": "https://doi.org/10.3892/or.2016.5259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27878272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27878272"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2017.4155"}], "href": "https://doi.org/10.3892/ijo.2017.4155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29039480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29039480"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Sotirios G Papageorgiou, Christos K Kontos, Panagiotis Tsiakanikas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated miR-20b-5p expression in peripheral blood mononuclear cells: A novel, independent molecular biomarker of favorable prognosis in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2018.04.014"}], "href": "https://doi.org/10.1016/j.leukres.2018.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29715621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29715621"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dongxin Tang, Zhu Yang, Fengxi Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28687"}], "href": "https://doi.org/10.1002/jcp.28687"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31012108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31012108"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Pengfei Wu, Jinquan Cai, Qun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lnc-TALC promotes O"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10025-2"}], "href": "https://doi.org/10.1038/s41467-019-10025-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31053733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31053733"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Haiqian Xu, Wenjie Li, Sai Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adipose derived stem cells promote tumor metastasis in breast Cancer cells by stem cell factor inhibition of miR20b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2019.109350"}], "href": "https://doi.org/10.1016/j.cellsig.2019.109350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31254605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31254605"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Greta Streleckiene, Ruta Inciuraite, Simonas Juzenas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21030877"}], "href": "https://doi.org/10.3390/ijms21030877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32013265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32013265"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Zhi-Jun Zhang, Xing-Guo Song, Li Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating serum exosomal miR-20b-5p and miR-3187-5p as efficient diagnostic biomarkers for early-stage non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Biol Med (Maywood) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1535370220945987"}], "href": "https://doi.org/10.1177/1535370220945987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32741216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32741216"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hui Yang, Jian Lin, Jinling Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-20b-5p functions as tumor suppressor microRNA by targeting cyclinD1 in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1829824"}], "href": "https://doi.org/10.1080/15384101.2020.1829824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33044899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33044899"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Renzhu Pang, Shuai Yang "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA DUXAP8 inhibits papillary thyroid carcinoma cell apoptosis via sponging the miR‑20b‑5p/SOS1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8015"}], "href": "https://doi.org/10.3892/or.2021.8015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33760128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33760128"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Zhuokai Li, Lvzhong Wu, Wei Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20b-5p promotes hepatocellular carcinoma cell proliferation, migration and invasion by down-regulating CPEB3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hepatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.aohep.2021.100345"}], "href": "https://doi.org/10.1016/j.aohep.2021.100345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33812045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33812045"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Kexin Jiang, Huawei Zou "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-20b-5p overexpression combing Pembrolizumab potentiates cancer cells to radiation therapy via repressing programmed death-ligand 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2014617"}], "href": "https://doi.org/10.1080/21655979.2021.2014617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34968160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34968160"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Karine Giraud-Triboult, Christelle Rochon-Beaucourt, Xavier Nissan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00077.2010"}], "href": "https://doi.org/10.1152/physiolgenomics.00077.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21081659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21081659"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Wen Wang, Lin Feng, Honghai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2011-3131"}], "href": "https://doi.org/10.1210/jc.2011-3131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22438230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22438230"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Nie Chunjie, Nie Huijuan, Yin Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disease-specific signature of serum miR-20b and its targets IL-8 and IL-25, in myasthenia gravis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Cytokine Netw (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1684/ecn.2015.0367"}], "href": "https://doi.org/10.1684/ecn.2015.0367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26845056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26845056"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Bo Qin, Jinwen Liu, Shenwen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20b targets AKT3 and modulates vascular endothelial growth factor-mediated changes in diabetic retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmw065"}], "href": "https://doi.org/10.1093/abbs/gmw065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27421659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27421659"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Pooi-Fong Wong, Juliana Jamal, Kind-Leng Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microvasc Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mvr.2017.06.002"}], "href": "https://doi.org/10.1016/j.mvr.2017.06.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28595801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28595801"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jun Lou, Yongli Wang, Zhimin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2017.06.007"}], "href": "https://doi.org/10.1016/j.yexcr.2017.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28606793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28606793"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Olfat G Shaker, Omayma O Abdelaleem, Rania H Mahmoud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic and prognostic role of serum miR-20b, miR-17-3p, HOTAIR, and MALAT1 in diabetic retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.1970"}], "href": "https://doi.org/10.1002/iub.1970"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30468285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30468285"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Shuxia Jiang, Xi Fang, Mingni Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20b Down-Regulates Intestinal Ferroportin Expression In Vitro and In Vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8101135"}], "href": "https://doi.org/10.3390/cells8101135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31554201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31554201"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Ke Zhu, Xin Hu, Han Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.10.004"}], "href": "https://doi.org/10.1016/j.ebiom.2019.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31636010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31636010"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yuan Xiong, Lang Chen, Chenchen Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating Exosomal miR-20b-5p Inhibition Restores Wnt9b Signaling and Reverses Diabetes-Associated Impaired Wound Healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Small (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/smll.201904044"}], "href": "https://doi.org/10.1002/smll.201904044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31867895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31867895"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Lihui Tai, Chiu-Jung Huang, Kong Bung Choo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative Stress Down-Regulates MiR-20b-5p, MiR-106a-5p and E2F1 Expression to Suppress the G1/S Transition of the Cell Cycle in Multipotent Stromal Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.38832"}], "href": "https://doi.org/10.7150/ijms.38832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32174776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32174776"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Ya-Fei Liu, Guo-Lan Xing, Zhe Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HOTAIR knockdown alleviates gouty arthritis through miR-20b upregulation and NLRP3 downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1874696"}], "href": "https://doi.org/10.1080/15384101.2021.1874696"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33467979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33467979"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Ruizhi Wang, Nipun Chopra, Kwangsik Nho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences Alzheimer's biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41380-021-01351-3"}], "href": "https://doi.org/10.1038/s41380-021-01351-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35087196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35087196"}]}]}]}