{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent genome‐wide association studies have implicated MIR2113 in the modulation of cognitive function. In one large meta‐analysis of middle‐aged and older adults, a single‐nucleotide polymorphism proximal to MIR2113 was significantly associated with general cognitive ability, suggesting that variants in this locus contribute to neuropsychiatric phenotypes in a polygenic manner. Further, in a community‐based cohort study, a specific MIR2113 allele was found to be linked with an accelerated decline in episodic memory over time, underscoring its potential role in cognitive aging and the modulation of memory-related processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of hepatocellular carcinoma, miR‑2113 has been shown to exert tumor‐suppressive effects. Research focusing on the interplay between the RNA-binding protein eIF4AIII and miR‑2113 demonstrated that enhancing miR‑2113 levels attenuates cell proliferation, migration, and the epithelial–mesenchymal transition by downregulating the target gene WDR66. This antagonistic regulation suggests that miR‑2113 not only modulates oncogenic signaling pathways but also may offer a novel therapeutic angle in the treatment of HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPreliminary analyses have also explored the role of MIR2113 in the susceptibility to other complex disorders, such as chronic obstructive pulmonary disease (COPD). Although the precise mechanisms remain to be fully elucidated, these investigations hint at a broader impact of MIR2113 variants in conferring risk to diseases beyond cognitive dysfunction and cancer, warranting further research into its multifaceted functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G Davies, N Armstrong, J C Bis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2014.188"}], "href": "https://doi.org/10.1038/mp.2014.188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25644384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25644384"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S J Andrews, D Das, K J Anstey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of AKAP6 and MIR2113 with cognitive performance in a population-based sample of older adults."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gbb.12368"}], "href": "https://doi.org/10.1111/gbb.12368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28067462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28067462"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Zhang, Yangzong Chen, Chunchun Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial-mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA-2113."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29475"}], "href": "https://doi.org/10.1002/jcp.29475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31975383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31975383"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jing Jing, Dan Xu, Zheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pulm Pharmacol Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pupt.2020.101945"}], "href": "https://doi.org/10.1016/j.pupt.2020.101945"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32931917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32931917"}]}]}]}