| HGNC Family | Non-coding RNAs |
| Name | microRNA 2115 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study represented by"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "investigates the molecular underpinnings of hepatocellular carcinoma (HCC) by focusing on the involvement of long noncoding RNAs, particularly lncRNA‐SNHG4. While the research delineates the oncogenic processes mediated by this lncRNA in HCC progression, it does not include a direct discussion of MIR2115. Based on current knowledge, MIR2115—like other microRNAs—is generally understood to regulate gene expression post‐transcriptionally, yet its specific role or interaction within the context of this study remains unaddressed."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis duis mauris potenti non at sociosqu ultricies massa. The abstract underscores the complexity of regulatory RNA networks in cancer while leaving open the possibility that MIR2115 could participate in fine‐tuning these pathways, either by modulating mRNA targets or influencing other regulatory RNAs. However, the available data from this abstract do not provide experimental or correlative insights into MIR2115’s function in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Fusce class lectus fringilla commodo sit blandit pellentesque. In summary, although the study offers a valuable framework for understanding lncRNA‐mediated mechanisms in hepatocellular carcinoma, it does not detail the role of MIR2115. Future investigations are needed to evaluate if MIR2115 interacts with molecules such as lncRNA‐SNHG4 and to determine its impact on tumor biology, potentially elucidating new avenues for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiannan Qiu, Peng Wang, Zheng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.5559"}], "href": "https://doi.org/10.1002/cam4.5559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36565037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36565037"}]}]}]}
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| NCBI Gene ID | 100313840 |
| API | |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR2115 has 93 functional associations with biological entities spanning 1 categories (cell line, cell type or tissue) extracted from 1 datasets.
Click the + buttons to view associations for MIR2115 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR2115 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |