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High‐resolution copy‐number analyses and luciferase reporter assays have demonstrated that miR‐218 modulates critical signaling cascades—including the IKKβ/NF‐κB and mTOR–Akt pathways as well as regulators of the cell cycle (for example, CDK6 and cyclin D1)—thus curtailing tumor cell proliferation and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several malignancies the downregulation of miR‐218 occurs through its sequestration by oncogenic non‐coding RNAs. For instance, long non‐coding RNAs such as CCAT1 and Linc00173 have been shown to “sponge” miR‐218, thereby preventing it from repressing its targets and facilitating tumor progression. 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