{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐218, including its paralog miR‐218‐2 encoded within the intronic region of SLIT3, has emerged as a multifaceted tumor suppressor across a broad spectrum of neoplasms. Multiple studies have shown that loss or downregulation of miR‐218 is associated with tumor progression in nasopharyngeal, lung, cervical, and glioblastoma cancers. In these settings, miR‐218 exerts its anti‐tumor activities by directly targeting key oncogenic transcripts—such as ROBO1, survivin (BIRC5), LEF1, and cell cycle‐regulatory proteins—and by modulating pathways that govern cell proliferation, migration, invasion, and metastasis. In addition, miR‐218 is physiologically induced by developmental regulators (e.g. the Isl1–Lhx3 complex) to promote proper motor neuron differentiation, underscoring its critical role in both developmental and oncogenic contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn numerous malignancies, restoration of miR‐218 expression has been shown to induce cell cycle arrest, enhance apoptosis, reverse epithelial–mesenchymal transition (EMT), and inhibit angiogenesis. For instance, in cervical, colorectal, gastric, and non‐small cell lung cancers, miR‐218 directly targets oncogenic drivers—including EGFR, CDK6, cyclin D1, RUNX2, and HMGB1—to sensitize cancer cells to chemotherapeutic agents such as 5‐fluorouracil, cisplatin, and paclitaxel. Moreover, through modulation of vital signaling cascades including the Wnt/β‐catenin and PI3K/AKT pathways, miR‐218 effectively curtails invasive behavior and improves therapeutic responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical tumor‐suppressive functions, miR‐218 participates in diverse regulatory networks that extend to non‐oncogenic processes. It influences metabolic homeostasis by targeting the adiponectin receptor AdipoR2, regulates melanogenesis via modulation of MITF, and controls mitochondrial quality through inhibition of PRKN‐mediated mitophagy. 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"}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3386"}], "href": "https://doi.org/10.3892/or.2014.3386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25110121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25110121"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Libin Zhang, Jing Hu, Jiagui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC-PINT inhibits non-small cell lung cancer progression through sponging miR-218-5p/PDCD4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1605371"}], "href": "https://doi.org/10.1080/21691401.2019.1605371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31010333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31010333"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Zhong-Di Xiao, Chun-Yu Jiao, Hai-Tao Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-218 modulate hepatocellular carcinoma cell proliferation through PTEN/AKT/PI3K pathway and HoxA10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25120782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25120782"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Lei Song, Dan Li, Yingkai Zhao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Urinary Exosome miR-424 and miR-218 as Biomarkers for Type 1 Diabetes in Children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2018.180921"}], "href": "https://doi.org/10.7754/Clin.Lab.2018.180921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31232015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31232015"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Katharina Ilm, Steffen Fuchs, Giridhar Mudduluru, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The impact of pri-miR-218 rs11134527 on the risk and prognosis of patients with esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25337271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25337271"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Xiaomin Li, Jiefeng He, Xiaojing Ren, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Expression of serum miR-218 in hepatocellular carcinoma and its prognostic significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-015-1447-z"}], "href": "https://doi.org/10.1007/s12094-015-1447-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26586116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26586116"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Juanhua Tian, Haibao Zhang, Lijun Mu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association of a potential functional pre-miR-218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Liver Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/liv.12313"}], "href": "https://doi.org/10.1111/liv.12313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24118778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24118778"}]}, {"type": "r", "ref": 48, "children": [{"type": "t", "text": "Yong Gao, Laisheng Sun, Zicheng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑218 inhibits the proliferation of human glioma cells through downregulation of Yin Yang 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.8063"}], "href": "https://doi.org/10.3892/mmr.2017.8063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29138857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29138857"}]}, {"type": "r", "ref": 49, "children": [{"type": "t", "text": "Hechun Du, Zimu Fu, Guohua He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-218 targets adiponectin receptor 2 to regulate adiponectin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.3282"}], "href": "https://doi.org/10.3892/mmr.2015.3282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25634129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25634129"}]}, {"type": "r", "ref": 50, "children": [{"type": "t", "text": "Yue Zhao, Rui Yao "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1978196"}], "href": "https://doi.org/10.1080/21655979.2021.1978196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34698001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34698001"}]}]}]}